61350-62-7

61350-62-7 - Names and Identifiers

Name	(R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride
Synonyms	(R)-benzyl 2-(chlorocarbonyl)pyrrolidine-1-carboxylate (R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride 1-Pyrrolidinecarboxylic acid, 2-(chlorocarbonyl)-, phenylmethyl ester, (2R)-
CAS	61350-62-7

61350-62-7 - Physico-chemical Properties

Molecular Formula	C13H14ClNO3
Molar Mass	267.70816

61350-62-7 - Upstream Downstream Industry

Downstream Products

(R)-5-BROMO-3-[(1-METHYL-2-PYRROLIDINYL)METHYL]-1H-INDOLE

61350-62-7 - Introduction

(R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride is a chemical substance whose molecular formula is C18H20ClNO3. The following is a detailed description of the properties, uses, preparation and safety information of the compound:

Nature:
(R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride is a solid with a white to yellowish color. It is insoluble in water at room temperature, but soluble in organic solvents such as ether, methanol and chloroform. Its melting point is about 65-70°C.

Use:
This compound is an important intermediate in organic synthesis. It is widely used in the field of drug synthesis, especially plays an important role in the synthesis of chiral compounds or drugs. It can be used to synthesize anticancer drugs, anti-inflammatory drugs, antibiotics and other bioactive molecules.

Method:
The preparation of (R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride generally involves two steps. First, benzylchloroformyl chloride (benzyl chloroformate) is reacted with 2-pyrrolidone (2-pyrrolidinone) by an appropriate reaction to give (R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinone this intermediate. The resulting intermediate is then converted to (R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride using sublimation or crystallization methods.

Safety Information:
(R)-N-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarbonyl chloride is a chemical that requires compliance with appropriate safety procedures. It may be irritating to the eyes, skin and respiratory system, so contact with skin, eyes and inhalation of its volatiles should be avoided at the time of contact. Wear appropriate personal protective equipment, such as goggles, gloves and protective masks. If contact or inhalation occurs, rinse immediately with plenty of water and seek medical help. During storage and handling, contact with oxidizing agents and strong acids should be avoided. Detailed safety information can be found in the relevant information.

Last Update：2024-04-09 21:01:54