68592-15-4
4-O-Methyl honokiol
CAS: 68592-15-4
Molecular Formula: C19H20O2
68592-15-4 - Names and Identifiers
| Name | 4-O-Methyl honokiol |
| Synonyms | 4-O-Methyl honokiol 4'-Methoxy-3',5-di-2-propenyl-(1,1'-biphenyl)-2-ol 2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol [1,1'-Biphenyl]-2-ol, 4'-methoxy-3',5-di-2-propen-1-yl- |
| CAS | 68592-15-4 |
68592-15-4 - Physico-chemical Properties
| Molecular Formula | C19H20O2 |
| Molar Mass | 280.36 |
| Boling Point | 396.5°C at 760 mmHg |
| Solubility | Soluble in DMSO |
| Appearance | Solid |
| Storage Condition | 2-8°C |
| MDL | MFCD19705288 |
| In vitro study | 4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells. |
| In vivo study | 4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues. 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ 1-42 accumulation, and activates astrocytes and microglia in LPS-injected mice brain. |
68592-15-4 - Reference Information
| biological activity | 4-o-methylhonokiol is a lignan compound isolated from Magnolia officinalis, which is a PPAR gamma agonist, can inhibit the activity of NF-κB, for cancer, inflammation and other research. |
| Use | for content determination/identification/pharmacological experiments. |
Last Update：2024-04-09 20:52:54
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Multiple SpecificationsSpot supply
Product Name: 4-O-Methyl honokiol Visit Supplier Webpage Request for quotationCAS: 68592-15-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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