7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸
Clinafloxacin
CAS: 105956-97-6
Molecular Formula: C17H17ClFN3O3
7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸 - Names and Identifiers
7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸 - Physico-chemical Properties
| Molecular Formula | C17H17ClFN3O3 |
| Molar Mass | 365.79 |
| Density | 1.573±0.06 g/cm3(Predicted) |
| Melting Point | 253-258 C |
| Boling Point | 592.3±50.0 °C(Predicted) |
| Flash Point | 312°C |
| Solubility | Acetic Acid (Slightly), DMSO (Slightly) |
| Vapor Presure | 7.14E-15mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Beige |
| pKa | 6.39±0.50(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.684 |
| In vitro study | Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid class that is currently used for intravenous and oral treatment of serious infections. Clinafloxacin is a new type of fluoroquinolone. It has broad spectrum activity against Gram-positive, Gram-negative, and anaerobic pathogens in vitro. Clinafloxacin had high activity against Streptococcus pneumoniae 7785 (MIC,0.125 μg/ml), and non-gyrA or parC quinolone-resistant mutations alone had a better effect on this activity. Compared to ofloxacin,levofloxacin,sparfloxacin,grepafloxacin, and trovafloxacin, Clinafloxacin is considered the most effective fluoroquinolone against S. pneumoniae and is currently considered an antistreptococcus pneumoniae drug. |
| In vivo study | Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis. |
7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R63 - Possible risk of harm to the unborn child |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| RTECS | VB1800600 |
7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸 - Reference
| Reference Show more | 1. [IF=6.057] Song Hu et al."Reliable performance of aggregation-induced emission nanoparticle-based lateral flow assay for norfloxacin detection in nine types of animal-derived food."Talanta. 2020 Nov;219:121245 |
7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.734 ml | 13.669 ml | 27.338 ml |
| 5 mM | 0.547 ml | 2.734 ml | 5.468 ml |
| 10 mM | 0.273 ml | 1.367 ml | 2.734 ml |
| 5 mM | 0.055 ml | 0.273 ml | 0.547 ml |
Last Update：2024-01-02 23:10:35
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7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸
6-甲基-2-氨基吡啶
桑辛素(桑根皮素,桑根白皮素)
1-氨基-1-环戊基甲醇
Sodium taurochenodeoxycholate
2-氯甲基-3-氟吡啶
4-氨基-6-氯-5-氨基嘧啶
1-Iodooctane (stabilized with Copper chip)
2-氨基-5-二乙氨基戊烷
2-羟基-3-三氟甲基-5-硝基吡啶
6-甲基-2-氨基吡啶
桑辛素(桑根皮素,桑根白皮素)
1-氨基-1-环戊基甲醇
Sodium taurochenodeoxycholate
2-氯甲基-3-氟吡啶
4-氨基-6-氯-5-氨基嘧啶
1-Iodooctane (stabilized with Copper chip)
2-氨基-5-二乙氨基戊烷
2-羟基-3-三氟甲基-5-硝基吡啶