7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE
7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE
CAS: 81935-60-6
Molecular Formula: C19H14ClN3O2
7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE - Names and Identifiers
7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE - Physico-chemical Properties
| Molecular Formula | C19H14ClN3O2 |
| Molar Mass | 351.79 |
| Density | 1.438±0.06 g/cm3 (20 ºC 760 Torr) |
| Physical and Chemical Properties | Crystallization. Melting point 258-264 ℃. |
7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE - References
| Use | An intermediate of ronalidione phosphate hydrochloride. |
| Production method | Nitration with 2-aminopyridine with mixed acid to generate 2-amino-5-nitropyridine, and liquid alkali hydrolysis to remove the amino group to obtain 2-Hydroxy-5-nitropyridine is then chlorinated with phosphorus oxychloride to obtain 2-chloro-5-nitropyridine, which is refluxed with methanol and sodium methoxide, 2-methoxy-5-nitropyridine is obtained by etherification, and its nitro group is reduced to amino group with iron powder-acetic acid, and then condensed with 2, 4-dichlorobenzoic acid to obtain 5-(5-chloro-2-carboxyanilino)-2-methoxypyridine, and then cycled under the action of phosphorus oxychloride to obtain 7, 10-dichloro-2-methoxybenzo [B]-1, 5-naphthalidine, finally, it is condensed with p-aminophenol in the presence of sulfuric acid to obtain the product. |
Last Update：2024-04-09 20:02:46
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Mobile: 86+15671228036
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