7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE

7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE - Names and Identifiers

Name	7-(Trifluoromethyl)-4-quinolinol
Synonyms	7-(trifluorophenyl)quinolin-4-ol 7-(Trifluoromethyl)-4-quinolinol 7-(trifluoromethyl)quinolin-4-ol 7-(TRIFLUOROMETHYL)-4-QUINOLINOL 7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE 4-HYDROXY-7-(TRIFLUOROMETHYL)QUINOLINE 4-Hydroxy-7-(trifluoromethyl)quinoline 7-(2,3,4-trifluorophenyl)-1H-quinolin-4-one
CAS	322-97-4
EINECS	206-298-0
InChI	InChI=1/C15H8F3NO/c16-11-4-3-9(14(17)15(11)18)8-1-2-10-12(7-8)19-6-5-13(10)20/h1-7H,(H,19,20)
InChIKey	OWPLFJSQLPTCHS-UHFFFAOYSA-N

7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE - Physico-chemical Properties

Molecular Formula	C10H6F3NO
Molar Mass	213.16
Density	1.3581 (estimate)
Melting Point	266-269°C(lit.)
Boling Point	311.9±37.0 °C(Predicted)
Appearance	Powder
Color	Light grayish to beige
pKa	3.79±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.629

7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29334990
Hazard Class	IRRITANT

7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE - Introduction

7-(Trifluoromethyl)-4-quinolinol, also known as 7-(Trifluoromethyl)-4-quinolinol, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 7-(Trifluoromethyl)-4-quinolinol is a white to light yellow crystalline or powdery solid.
-Solubility: It has good solubility in common organic solvents.

Use:
-Chemical reagent: 7-(Trifluoromethyl)-4-quinolinol can be used as a reagent in organic synthesis reactions, such as selective dehydration, oxidation and reduction of aldehyde groups.
-Drug research: It is widely used as an intermediate and reagent for drug synthesis in drug research.

Method:
7-(Trifluoromethyl)-4-quinolinol can be prepared by the following steps:
-The first step: 4-chloroquinoline reacts with trifluoromethyl alcohol to produce 4-chloro-7-trifluoromethylquinoline.
-The Second step: 4-chloro-7-trifluoromethylquinoline is catalytically reduced with aluminum powder in water to obtain 7-(Trifluoromethyl)-4-quinolinol.

Safety Information:
- 7-(Trifluoromethyl)-4-quinolinol has low toxicity, but as an organic compound, it is still necessary to pay attention to safe operation.
-It may be irritating to the eyes and skin, and direct contact should be avoided when in contact.
-Follow Good Laboratory safety practices, such as wearing gloves, glasses and protective clothing.

Last Update：2024-04-09 19:05:49