8-(2-羟基苯甲酰胺基)辛酸钠
Salcaprozate Sodium
CAS: 203787-91-1
Molecular Formula: C15H20NNaO4
8-(2-羟基苯甲酰胺基)辛酸钠 - Names and Identifiers
8-(2-羟基苯甲酰胺基)辛酸钠 - Physico-chemical Properties
| Molecular Formula | C15H20NNaO4 |
| Molar Mass | 301.31 |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Bioactive Salcaprozate sodium (SNAC) is an oral absorption promoter with potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium can increase the lipophilicity caused by non-covalent macromolecular complexation, thereby increasing the passive transcellular penetration of small intestinal epithelial cells. |
| Use | Introduction 8-(2-hydroxybenzamido) sodium octanoate, SNAC for short, is a two-carbon phosphate compound absorption enhancer, used in the treatment of gastrointestinal diseases, it is especially suitable for gastrointestinal diseases caused by malabsorption of two carbon phosphate compounds. |
8-(2-羟基苯甲酰胺基)辛酸钠 - Uses and synthesis methods
in vitro study
SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL.
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution.
in vivo studies
SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats.
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident.
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d.
Animal Model: Sprague-Dawley rats (6-7 weeks)
Dosage: 2000 mg/kg/d
Administration: Oral gavage for 13 weeks
Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.
Last Update：2024-04-09 21:01:54
8-(2-羟基苯甲酰胺基)辛酸钠 - Nature
| storage conditions | Inert atmosphere,Room Temperature |
Last Update：2024-04-09 01:59:49
Supplier List
Featured Products
Product Name: Salcaprozate Sodium Request for quotationCAS: 203787-91-1
Tel: +86 0512-68417696
Email: chenmengqi@highfine.com
wuhao@highfine.com
merry@highfine.com
QQ: 4006286883
Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 203787-91-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Salcaprozate Sodium Request for quotationCAS: 203787-91-1
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: Salcaprozate Sodium Request for quotationCAS: 203787-91-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: Salcaprozate sodium Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Salcaprozate sodium Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 203787-91-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Featured Products
Product Name: Salcaprozate Sodium Request for quotationCAS: 203787-91-1
Tel: +86 0512-68417696
Email: chenmengqi@highfine.com
wuhao@highfine.com
merry@highfine.com
QQ: 4006286883
Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 203787-91-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Salcaprozate Sodium Request for quotationCAS: 203787-91-1
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: Salcaprozate Sodium Request for quotationCAS: 203787-91-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: Salcaprozate sodium Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Salcaprozate sodium Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotationCAS: 203787-91-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 203787-91-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
View History
8-(2-羟基苯甲酰胺基)辛酸钠
2-([2-(PHENYLCARBONYL)HYDRAZINO]CARBONYL)BENZOIC ACID
全氟(4-甲基-2-戊烯)
4-氯邻苯二酸
5-氯-2-金刚烷酮
柠檬酸一水合物
4-PHENYL-4-PIPERIDINECARBONITRILE HCL
杜邦AmberLite™HPR9200Cl离子交换树脂
AMINO TEREPHTHALATE DIMETHYL ESTER
4-[(2-呋喃基甲基)硫]-4-甲基戊-2-酮
2-([2-(PHENYLCARBONYL)HYDRAZINO]CARBONYL)BENZOIC ACID
全氟(4-甲基-2-戊烯)
4-氯邻苯二酸
5-氯-2-金刚烷酮
柠檬酸一水合物
4-PHENYL-4-PIPERIDINECARBONITRILE HCL
杜邦AmberLite™HPR9200Cl离子交换树脂
AMINO TEREPHTHALATE DIMETHYL ESTER
4-[(2-呋喃基甲基)硫]-4-甲基戊-2-酮