8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE - Names and Identifiers

Name	8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE
Synonyms	8-METHOXY-A-TETRALONE 8-METHOXY-1-TETRALONE 8-Methoxy-α-Tetralone 8-Methoxy-3,4-dihydronaphthalen-1-one 3,4-Dihydro-8-methoxy-1(2H)-naphthalenone 8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 1(2H)-Naphthalenone, 3,4-dihydro-8-Methoxy- 8-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one
CAS	13185-18-7

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE - Physico-chemical Properties

Molecular Formula	C11H12O2
Molar Mass	176.21
Density	1.124
Melting Point	128-130℃
Boling Point	325℃
Flash Point	155℃
Storage Condition	Sealed in dry,Room Temperature

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE - Risk and Safety

Hazard Class

IRRITANT

8-METHOXY-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE - Reference Information

Use

8-methoxy-A-tetrahydronaphthone is an organic intermediate, and it has been reported in the literature that it can be used to prepare RORγ regulators.

preparation

1) compound 1(1.0g,6.25mmol,1.0eq) and alcl (4.2g,31.50mmol,5.0eq) were added into 30mL cyclohexane at room temperature, the tube was sealed at 110 ℃, and stirred for 2 hours. TLC showed that Compound 1 reacted completely. Add 100mL of ice water to the reaction solution and extract it 3 times with 50mL DCM. The organic phase was washed with 100mL saturated sodium chloride and dried with anhydrous sodium sulfate. The compound 2(0.3g, yield 30%) was obtained by rotating the prep-HPLC under reduced pressure. 2) Compound 2(1.6g,9.9mmol,1.0eq),KCO(5.5g,39.6mmol,4.0eq) and 20mL acetone were added. Seal the pipe and stir at 80 ℃ for 6 hours. TLC showed disappearance of compound 2. The reduced pressure solution of the reaction solution was swirled through the column (PE/EA = 10:1-4:1) to obtain compound 3(0.4g, yield: 25%).

Last Update：2024-04-10 22:29:15