872038-32-9

872038-32-9 - Names and Identifiers

Name	4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane
Synonyms	4-(Trifluoromethoxy)phenylmethylboronic acid, pinacol ester 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[[4-(trifluoromethoxy)phenyl]methyl]-
CAS	872038-32-9
InChI	InChI=1/C14H18BF3O3/c1-12(2)13(3,4)21-15(20-12)9-10-5-7-11(8-6-10)19-14(16,17)18/h5-8H,9H2,1-4H3

872038-32-9 - Physico-chemical Properties

Molecular Formula	C14H18BF3O3
Molar Mass	302.1
Density	1.139g/mLat 25°C
Boling Point	100°C/0.2mmHg
Flash Point	105°C
Vapor Presure	0.00453mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.458

872038-32-9 - Risk and Safety

WGK Germany

872038-32-9 - Introduction

4,4, 5,5-tetraethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane is an organic compound with the formula C14H16BF3O3. The following is a description of some properties, uses, preparation and safety information about the compound:

Nature:
-Appearance: colorless liquid
-Boiling point: about 130-135°C
-Density: about 1.24g/cm³
-Melting point: about -25°C
-Solubility: Soluble in common organic solvents such as ethers and ketones

Use:
- 4,4, 5,5-tetrathyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane is an important intermediate in organic synthesis, which is commonly used to catalyze cross-coupling reactions, such as Suzuki reaction and ternary coupling reaction.
-It can also be used as a reagent and catalyst in organic synthesis, usually used to synthesize compounds containing aromatic groups and carbon-oxygen bonds.
-The compound also has potential applications in the field of medicine, such as fluorescent dyes, heterocyclic synthesis, and synthesis of anti-tumor and antiviral drugs.

Preparation Method:
- 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane is prepared by a complicated method. Generally, benzylboronic acid pinacol ester reacts with trifluoromethanol, and the target product is obtained through a multi-step reaction.

Safety Information:
- 4,4,5,5-tetramethyl-2-[4-(trifluoromethoxy)benzyl]-1,3,2-dioxaborolane for specific hazards and safety measures need to refer to the label and safety instructions on the chemical packaging.
-When using and handling this compound, wear suitable protective equipment, such as chemical protective gloves and protective glasses, and avoid contact with skin and eyes.
-In addition, it should be used in a well-ventilated place and follow the prescribed handling and storage methods. In the event of any negative reaction or accident, immediately take appropriate emergency measures and seek professional medical help.

Last Update：2024-04-09 20:52:54