Name | CNT2 inhibitor-1 |
Synonyms | 880155-70-4 CNT2 inhibitor-1 Adenosine, 8-[([1,1'-biphenyl]-4-ylmethyl)amino]- (9CI) |
CAS | 880155-70-4 |
Molecular Formula | C23H24N6O4 |
Molar Mass | 448.47 |
Density | 1.57±0.1 g/cm3(Predicted) |
Boling Point | 807.5±75.0 °C(Predicted) |
pKa | 13.07±0.70(Predicted) |
Storage Condition | 2-8℃ |
Use | CNT2 inhibitor-1 is a potent inhibitor of concentrated nucleoside transporter 2 (CNT2) with an IC50 value of 640 nM for human cnt2. |
In vitro study | CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors. CNT2 inhibitor-1 (compound 1) is a potent inhibitor with poor solubility. |