9-(3-Amino-2,3-dideoxy-β-D-ribofuranosyl)guanine

9-(3-Amino-2,3-dideoxy-β-D-ribofuranosyl)guanine - Names and Identifiers

Name	3'-Amino-2',3'-dideoxyguanosine
Synonyms	3'-NH2-ddG 3'-AMINO-2'-DEOXY-D- GUANOSINE 3'-AMINO-2',3'-DIDEOXYGUANOSINE 3'-Amino-2',3'-dideoxyguanosine Guanosine,3'-aMino-2',3'-dideoxy- 3'-Amino-2',3'-dideoxy-D-guanosine 9-(3-Amino-2,3-dideoxy-β-D-ribofuranosyl)guanine 2-Amino-9-[(2R,4S,5S)-4-amino-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one 2-amino-9-[(2R,4S,5S)-4-amino-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6 -one 2-Amino-9-((2R,4S,5S)-4-amino-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
CAS	66323-49-7
InChI	InChI=1/C10H14N6O3/c11-4-1-6(19-5(4)2-17)16-3-13-7-8(16)14-10(12)15-9(7)18/h3-6,17H,1-2,11H2,(H3,12,14,15,18)/t4-,5+,6+/m0/s1

9-(3-Amino-2,3-dideoxy-β-D-ribofuranosyl)guanine - Physico-chemical Properties

Molecular Formula	C10H14N6O3
Molar Mass	266.26
Density	2.08g/cm³
Boling Point	662.4°C at 760 mmHg
Flash Point	354.4°C
Water Solubility	Soluble in water (50 mg/ml).
Vapor Presure	1.88E-18mmHg at 25°C
Appearance	Powder
Color	Off-white to Yellow
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.935
MDL	MFCD09750824

9-(3-Amino-2,3-dideoxy-β-D-ribofuranosyl)guanine - Introduction

3 '-Amino-2',3 '-dideoxyguanosine is a nucleoside analog with the formula C10H15N5O3. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
- 3 '-Amino-2',3 '-dideoxyguanosine is a white to pale yellow crystalline solid.
-It is insoluble in water, but soluble in some organic solvents, such as methanol and dimethyl sulfoxide.
-It is stable to heat and light, but easily degraded under acidic conditions.

Use:
- 3 '-Amino-2',3 '-dideoxyguanosine is commonly used to study the structure and function of RNA.
-It can be used as a probe for interaction with RNA to study the interaction mechanism between RNA and proteins, drugs, etc.
-Because it is a dideoxynucleoside, it can also be used to study the synthesis and degradation of DNA or RNA.

Preparation Method:
- 3 '-Amino-2',3 '-dideoxyguanosine is usually prepared by chemical synthesis.
-The specific preparation method includes the amination reaction of 2 ',3'-dideoxyguanosine to introduce an amino group into the 3 'position of the nucleoside.

Safety Information:
- 3 '-Amino-2',3 '-dideoxyguanosine is generally considered to have low toxicity under conventional conditions.
-Follow the laboratory's safe practices during operation, including wearing appropriate personal protective equipment.
-Hazardous environments such as exposure to heat, fire and strong acids should be avoided.

Last Update：2024-04-09 21:04:16