9-methoxy-7H-furo(3,2-g)benzopyran-7-one
Methoxsalen
CAS: 298-81-7
Molecular Formula: C12H8O4
9-methoxy-7H-furo(3,2-g)benzopyran-7-one - Names and Identifiers
| Name | Methoxsalen |
| Synonyms | MOP 8-MP 8-MOP Uvadex Meloxine Ammoidin xanthoxin 8-Methoxy Oxsoralen meladinin methoxalen zanthotoxin Methoxsalen Xanthotoxin oxypsoralen Psoralon-MOP psoralen-mop Methoxa-Dome proralone-mop 7-furocoumarin Oxsoralen Ultra Oxsoralen Lotion 9-Methoxypsoralen 8-Methoxypsoralen 8-Methoxyfuranocoumarin 8-methoxy-4',5',6,7-furocoumarin 8-methoxy-2',3',6,7-furocoumarin 8-Methoxy-2',3',6,7-furocoumarin 8-methoxy-2',3',6,7-furocoumarin 8-Methoxy-4',5',6,7-furocoumarin 9-methoxyfuro[3,2-g]chromen-7-one 9-methoxy-7H-furo[3,2-g]chromen-7-one 9-methoxy-7H-furo(3,2-g)benzopyran-7-one 2-g][1]benzopyran-7-one,9-methoxy-7h-furo[ 2-g)(1)benzopyran-7-one,9-methoxy-7h-furo( 6-hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone |
| CAS | 298-81-7 |
| EINECS | 206-066-9 |
| InChI | InChI=1/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3 |
9-methoxy-7H-furo(3,2-g)benzopyran-7-one - Physico-chemical Properties
| Molecular Formula | C12H8O4 |
| Molar Mass | 216.19 |
| Density | 1.1344 (rough estimate) |
| Melting Point | 148-150°C(lit.) |
| Boling Point | 276.6°C (rough estimate) |
| Flash Point | 204.7°C |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Solubility | Soluble in boiling ethanol, acetic acid, propylene glycol, chloroform and benzene, slightly soluble in boiling water, liquid paraffin and ether, insoluble in cold water. |
| Vapor Presure | 4.33E-07mmHg at 25°C |
| Appearance | White or light yellow crystals |
| Color | white to yellow |
| Merck | 14,5988 |
| BRN | 196453 |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Sensitive to light |
| Refractive Index | 1.4270 (estimate) |
| MDL | MFCD00005009 |
| Physical and Chemical Properties | Melting point 143-148°C water-soluble PRACTICALLY INSOLUBLE Merck 14,5988 BRN 196453 dangerous goods transport number 3216 WGK Germany 3 RCS telv140000 F 10 |
| Use | For the treatment of psoriasis, vitiligo and other diseases |
9-methoxy-7H-furo(3,2-g)benzopyran-7-one - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R43 - May cause sensitization by skin contact R46 - May cause heritable genetic damage R45 - May cause cancer R34 - Causes burns |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 3216 |
| WGK Germany | 3 |
| RTECS | LV1400000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29322090 |
| Toxicity | LD50 i.p. in rats: 470 ±30 mg/kg (Hakim) |
9-methoxy-7H-furo(3,2-g)benzopyran-7-one - Reference
| Reference Show more | 1. Dong Yupeng, Sun Ping, Li Yongcai, Bi Yang, Zhang Miao, Huang Yi, Zhang Tingting. Antibacterial effect and mechanism of trans-2-hexenal on pear fruit spot pathogen Alternaria alternata [J]. Food Science, 2020, 41(07): -197. 2. Xuelian Wang, Minmin Li, Junhua Hu, et al. Inhibitory effects of 18 coumarins on Colletotrichum gloeosporioides in Citrus [J]. Southern China fruit trees, 2013, 42(004):73-74. 3. Wu Wen Wu Rui Feng Kang Jiang Li. Study on the fingerprint and content determination of Shenling Jianwu powder [J]. China pharmacist 2019 22(05):852-856. 4. Zhang Ping, Ma Xiao, Li Donghua, etc. Analysis of National Evaluation of angelica dahurica pieces and study on multi-index component test and multi-evaluation method [J]. Chinese herbal medicine, 2019(14). 5. Yu Lan, Tang Hui, Chen Hanying, Wang Xiaoqin, Zhang Bo. Pharmacodynamic evaluation and mechanism of promoting zebrafish melanin production by methoxyflavone [J]. Chinese herbal medicine, 2020,51(23):6023-6034. 6. Yang, Yan-Fang, Lei Zhang, and Xiu-Wei Yang. "Distribution assessments of coumarins from Angelicae Pubescentis Radix in rat cerebrospinal fluid and brain by Liquid Chromatography Tandem Mass Spectrometry analysis." Molecules 23.1 (2018): 225.https://doi.or 7. [IF=7.514] Si-Duo Zhou et al."On-line screening and identification of free radical scavenging compounds in Angelica dahurica fermented with Eurotium cristatum using an HPLC-PDA-Triple-TOF-MS/MS-ABTS system."Food Chem. 2019 Jan;272:670 8. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 9. [IF=4.411] Liang Yang et al."New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum."Molecules. 2016 Apr;21(4):468 10. [IF=3.963] Zhongxiang Sun et al."Identification of a cytochrome P450 CYP6AB60 gene associated with tolerance to multi-plant allelochemicals from a polyphagous caterpillar tobacco cutworm (Spodoptera litura)."Pestic Biochem Phys. 2019 Feb;154:60 11. [IF=3.943] Liwei He et al."4(3H)-Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG-1 pathway in RAW264.7 cell."Int Immunopharmacol. 2017 Nov;52:245 12. [IF=5.81] Jiye Wang et al."Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods."Front Pharmacol. 2021; 12: 754175 13. [IF=5.753] Liu Man et al."Constructing a Core Collection of the Medicinal Plant Angelica biserrata Using Genetic and Metabolic Data."Front Plant Sci. 2020 Dec;0:2099 14. [IF=4.36] Yang Zhao et al."Shashen-Maidong Decoction improved chronic intermittent hypoxia-induced cognitive impairment through regulating glutamatergic signaling pathway."J Ethnopharmacol. 2021 Jun;274:114040 |
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