ADDA 5(ADDA5
ADDA 5 hydrochloride
CAS: 473268-46-1
Molecular Formula: C24H36ClNO2
ADDA 5(ADDA5 - Names and Identifiers
| Name | ADDA 5 hydrochloride |
| Synonyms | ADDA-5) ADDA 5 HCl 473268-46-1 ADDA 5 (ADDA5 ADDA 5 hydrochloride |
| CAS | 473268-46-1 |
ADDA 5(ADDA5 - Physico-chemical Properties
| Molecular Formula | C24H36ClNO2 |
| Molar Mass | 406.01 |
| Storage Condition | 2-8℃ |
| Use | ADDA 5 hydrochloride, a partially non-competitive inhibitor of cytochrome c oxidase (CcO), inhibits Cc isolated and purified from human glioma cells and bovine cardiomyocytes |
| In vitro study | ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC 50 s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC 50 s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC 50 of 8.17 μM. |
| In vivo study | ADDA 5 (8 mg/kg, i.p.) significantly suppresses the growth of tumor in mice. ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice. |
ADDA 5(ADDA5 - Introduction
ADDA 5 hydrochloride, chemical name 5-(v) amino-N,N-dimethyl -1-naphthalene acetamide hydrochloride, is an organic compound. Its chemical formula is C14H17N2O · HCl and its molecular weight is 276.76g/mol.
ADDA 5 hydrochloride has fluorescent properties and emits bright green fluorescence under yellow-green light. It is a white or almost white crystalline solid, soluble in water and alcoholic solvents.
The use of ADDA 5 hydrochloride is mainly focused on fluorescent dyes and biological fluorescent probes. It can be used for staining nuclei and chromosomes, for fluorescence microscopy in chemical and biological samples. In addition, it can also be used as a fluorescent probe for live cells and fixed cells for fluorescent labeling molecules and cell imaging.
The preparation of ADDA 5 hydrochloride can be obtained by chemical synthesis. A common synthetic route is to use 1-naphthalenone to react with dimethylhydrazine under acidic conditions to generate the intermediate of ADDA 5, and then react with hydrochloric acid to prepare ADDA 5 hydrochloride.
Regarding the safety information of ADDA 5 hydrochloride, it is a chemical that may have certain toxicity. Safety awareness should be strengthened during operation and storage. Avoid contact with skin, eyes and respiratory tract. Wear appropriate protective gloves and glasses during use and maintain a well-ventilated environment. In case of accidental contact, rinse immediately with plenty of water and seek medical help. The ADDA 5 hydrochloride should be stored in a dry, cool place, away from fire and oxidizing agents, and avoid mixing with other chemicals.
ADDA 5 hydrochloride has fluorescent properties and emits bright green fluorescence under yellow-green light. It is a white or almost white crystalline solid, soluble in water and alcoholic solvents.
The use of ADDA 5 hydrochloride is mainly focused on fluorescent dyes and biological fluorescent probes. It can be used for staining nuclei and chromosomes, for fluorescence microscopy in chemical and biological samples. In addition, it can also be used as a fluorescent probe for live cells and fixed cells for fluorescent labeling molecules and cell imaging.
The preparation of ADDA 5 hydrochloride can be obtained by chemical synthesis. A common synthetic route is to use 1-naphthalenone to react with dimethylhydrazine under acidic conditions to generate the intermediate of ADDA 5, and then react with hydrochloric acid to prepare ADDA 5 hydrochloride.
Regarding the safety information of ADDA 5 hydrochloride, it is a chemical that may have certain toxicity. Safety awareness should be strengthened during operation and storage. Avoid contact with skin, eyes and respiratory tract. Wear appropriate protective gloves and glasses during use and maintain a well-ventilated environment. In case of accidental contact, rinse immediately with plenty of water and seek medical help. The ADDA 5 hydrochloride should be stored in a dry, cool place, away from fire and oxidizing agents, and avoid mixing with other chemicals.
Last Update：2024-04-10 22:29:15
