ADENOSINE 5'-TRIPHOSPHATASE
ADENOSINE 5'-TRIPHOSPHATASE
CAS: 9000-83-3
Molecular Formula: C10H16N5O13P3
ADENOSINE 5'-TRIPHOSPHATASE - Names and Identifiers
| Name | ADENOSINE 5'-TRIPHOSPHATASE |
| Synonyms | ATPASE EC 3.6.1.3 ATP PHOSPHOHYDROLASE ADENOSINE 5'-TRIPHOSPHATASE ADENOSINE 5'-TRIPHOSPHATASE FROM RABBIT KIDNEY ADENOSINE 5'-TRIPHOSPHATASE FROMPORCINE CEREBRAL C |
| CAS | 9000-83-3 |
ADENOSINE 5'-TRIPHOSPHATASE - Physico-chemical Properties
| Molecular Formula | C10H16N5O13P3 |
| Appearance | lyophilized powder |
| Storage Condition | -20°C |
| Physical and Chemical Properties | White or off-white powder, odorless, tasteless, with hygroscopicity. Soluble in water, very slightly soluble in organic solvents. 1% aqueous solution pH 3~5. Unstable in alkaline solution. |
ADENOSINE 5'-TRIPHOSPHATASE - Risk and Safety
| WGK Germany | 3 |
ADENOSINE 5'-TRIPHOSPHATASE - Reference
| Reference Show more | 1. Jiang Yu, Zhang Miao, Tang Jing, Jin Peng, Zheng Yong Hua. Effects of cold shock combined with salicylic acid treatment on chilling injury and energy and proline metabolism of cucumber fruit [J]. Journal of Nuclear Agriculture, 2021,35(01):128-137. 2. Zhao Simin, bevenge, Bao Zeyang, Guan Feng, Yuan Yongjun. Study on the effect of fluidized ice on the preservation of large yellow croaker [J]. Science and Technology of food industry, 2021,42(01):297-303. 3. Hengchang Ma et al. [IF = 3.591]. "Multiple-phase linear polymers toward ATP sensing and a cell imaging application." New J Chem. 2018 Jun;42(12):9702-9708 Note: For some products, we can only provide some information, and we do not guarantee the authority of the information provided, for customer reference and communication purposes only. use: This product is for scientific research only, not for other purposes. storage conditions: -20 °c Appearance: Lyophilized powder Physical form, 0.4% EDTA Na4 and 0.06% NaCl Unit Definition:One unit will liberate 1.0 μmole of inorganic phosphorus from ATP per min at pH 7.8 at 37°C in the presence of Na+, K+, and Mg2+. |
ADENOSINE 5'-TRIPHOSPHATASE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| High-energy phosphate compounds | Adenosine triphosphate, also known as adenosine triphosphate, or ATP for short, is the most important high-energy phosphate compound in organisms and is the delivery of phosphate bonds. Coenzyme. It is almost the only energy that biological tissues and cells can directly use. Mammalian bones and muscles contain ATP350 ~ 400mg per 100g in the resting state. When muscle activity is stimulated, ADP (adenosine diphosphate) can be generated under the action of enzymes, and energy is released at the same time. It is often called the "universal currency" of the body ". A considerable part of the energy released by the energy substance through biological oxidation is stored in the ATP molecule in the form of high-energy phosphate bonds. It is also one of the raw materials for cell synthesis of nucleic acids, and as the main donor of phosphoryl groups to derive other types of nucleotides and phosphate compounds. The molecular structure of adenosine triphosphate is formed by three phosphoryl groups connected by pyrophosphate bonds, and then connected to adenosine 51-C through phosphate bonds. The structural formula of adenosine triphosphate is as follows: The molecule contains two high-energy phosphate bonds and has high phosphoryl transfer potential energy. A large amount of free energy can be generated during hydrolysis or phosphoryl transfer. When hydrolyzed to ADP and phosphoric acid, the free energy change of the reaction is -30.5 kJ · mol-1; when hydrolyzed to adenosine monophosphate (AMP) and pyrophosphate, the free energy change of the reaction is -31.8 kJ · mol-1. In organisms, the water liberation energy reaction is often coupled with the energy absorption reaction to promote the energy absorption reaction. Directly provide energy for life activities such as biosynthesis, active membrane transportation, muscle contraction, biological movement, and bioluminescence. In vivo, it can be synthesized from ADP through substrate level phosphorylation, oxidative phosphorylation and photosynthetic phosphorylation. It can be used as a medicine for medical care. |
| Biological characteristics of adenosine triphosphate | Adenosine triphosphate is the central substance of energy storage and release in organisms, high-energy bond compounds in cell mitochondria and chloroplasts, and substances in the body The energy produced by metabolism and the energy required for various physiological and biochemical functions can be converted through it. Adenosine triphosphate (ADP) and adenophosphorus (AMP) form an energy conversion system to provide available energy for the formation of yield and quality, and to ensure the needs of plant growth and development. It is also a donor of phosphoric acid, pyrophosphate or adenylate. Its function is shown in the figure. Adenosine triphosphate is a phosphate derivative of adenylate (AMP). When the two high-energy phosphate bonds contained in the molecule are hydrolyzed under enzyme catalysis, each bond can release 54.24kJ/mol of energy. The high-energy bond required for the synthesis of guanosine triphosphate (GTP) and cytidine triphosphate (CTP) is also transferred from adenosine triphosphate. It is clinically used for energy supplement, acute and chronic pneumonia, liver cirrhosis, progressive muscular atrophy, myocardial disease, etc., but the curative effect is still inconclusive. Exogenous adenosine triphosphate is not easy to penetrate the cell membrane, so intramuscular injection or intravenous drip is often used clinically. |
| Free energy | The so-called free energy is the energy that can do work under constant temperature and pressure. Complex nutrient molecules contain more free energy. Glucose and other energy substances of cells release free energy during oxidative decomposition, most of which is retained in the form of adenosine triphosphate (ATP), and a small part is lost in the form of heat energy. The free energy retained in the form of ATP can be used for work, such as muscle contraction (mechanical work) and biosynthesis (chemical work). Although heat energy can maintain the body temperature of higher animals, it cannot do work. Because this form of energy can only do work under constant pressure when it flows from a hotter object to a colder object, which is impossible in living cells. The cell is isothermal, that is, the temperature of each part is the same. The chemical energy retained in the form of ATP can be used for 4 types of work. One is to provide the chemical work required for biosynthesis. In this process, the terminal phosphate group of ATP is enzymatically transferred to various structural units, making it an activated precursor substance and preparing to be assembled into biological macromolecules. The second is the energy source for cell movement and contraction. The third is to move nutrients through the membrane from the low concentration to the high concentration. Fourth, in the process of DNA, RNA and protein synthesis, to ensure the precise transfer of genetic information. When the chemical energy of ATP is used in cell work, it loses its terminal phosphate group, turning it into inorganic phosphate (Pi), leaving ADP (sometimes AMP). In the coupling with the decomposition capacity of cell energy substances, ADP and Pi regenerate ATP. In this way, in the "energy cycle" of cells, ATP is a bridge between production capacity and energy demand processes. Adenylate and its phosphate compounds (pH7) (arrows indicate the breaking point when ATP is hydrolyzed to generate ADP) Reference materials: edited by Peng Yixin. Chinese Middle School Teaching Encyclopedia · Biology Volume. Shenyang: Shenyang Publishing House. 1990. p. 349. |
| Drug properties and applications | Adenosine triphosphate is a coenzyme that can improve the metabolism of the body and participate in the metabolism of body fat, protein, sugar, nucleic acid and nucleotides. At the same time, it is the most important and direct energy source for the body's metabolic activities, which can supply the energy required for absorption, secretion, muscle contraction and biochemical synthesis in the body. It has the effect of vasodilating, especially the dilating effect of coronary arteries, which makes blood pressure drop. It is suitable for diseases caused by cell damage and cell enzyme decline such as heart failure, myocarditis, cerebral arteriosclerosis, coronary arteriosclerosis, acute poliomyelitis, angina pectoris, tachycardia, progressive muscle atrophy, sequelae of cerebral hemorrhage and acute and chronic Hepatitis can also be used for tinnitus, neurological deafness, inner ear vertigo caused by various reasons. This product cannot penetrate the cell membrane, and whether it can exert its physiological effects is worth considering. In recent years, the popular clinical energy injection is a compound preparation of this product, coenzyme A, insulin, etc., used to treat hepatitis, nephritis, heart failure, coronary heart disease, etc. Recently, it has been found that this product can inhibit the calcium influx of slow-response fibers, block or delay the forward conduction of the atrioventricular node during reentry; large doses can block or delay the forward or reverse conduction of the bypass; in addition, there is a short-term enhancement The function of the vagus nerve can prevent arrhythmia caused by atrioventricular node reentry and bypass reentry. Used in the treatment of rapid supraventricular arrhythmia, the total effective rate can reach 82%. It has the advantages of fast cardioversion and can be reused in a short period of time. It can be used as the first choice for terminating acute supraventricular tachycardia. |
Last Update：2024-04-09 21:04:16
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CAS: 9000-83-3
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CAS: 9000-83-3
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View History
ADENOSINE 5'-TRIPHOSPHATASE
2-甲硫基-4-氨基嘧啶-5-羧酸乙酯
(2S,3R)-N-FMOC-2-氨基-3-羟基-4-甲基戊酸
TOSLAB 807924
4-氨基苯甲酰基甘氨酸钠
2-氰基苯溴化锌, 0.5M THF溶液, 氩气下用可重封的 CHEMSEAL 瓶包装
2-羟基-3-吡嗪羧酸甲酯
4-氯-3-甲氧基-2-氯甲基吡啶盐酸盐
13-CIS,16-CIS-DOCOSADIENOIC ACID
2-氨基-3-羟基-3-苯基丙酸乙酯盐酸盐
2-甲硫基-4-氨基嘧啶-5-羧酸乙酯
(2S,3R)-N-FMOC-2-氨基-3-羟基-4-甲基戊酸
TOSLAB 807924
4-氨基苯甲酰基甘氨酸钠
2-氰基苯溴化锌, 0.5M THF溶液, 氩气下用可重封的 CHEMSEAL 瓶包装
2-羟基-3-吡嗪羧酸甲酯
4-氯-3-甲氧基-2-氯甲基吡啶盐酸盐
13-CIS,16-CIS-DOCOSADIENOIC ACID
2-氨基-3-羟基-3-苯基丙酸乙酯盐酸盐