AESCIN IIB

Name	escin IIb
Synonyms	EscinID escin IIb ESCIN IIB 06035642G6 AESCIN IIB 2)]-β-D-glucopyranosiduronic acid b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]- β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-
CAS	158800-83-0
InChI	InChI=1/C54H84O23/c1-10-23(2)45(69)77-42-43(71-24(3)58)54(22-57)26(17-49(42,4)5)25-11-12-30-50(6)15-14-32(51(7,21-56)29(50)13-16-52(30,8)53(25,9)18-31(54)60)73-48-40(75-46-36(64)33(61)27(59)20-70-46)38(66)39(41(76-48)44(67)68)74-47-37(65)35(63)34(62)28(19-55)72-47/h10-11,26-43,46-48,55-57,59-66H,12-22H2,1-9H3,(H,67,68)/b23-10-/t26-,27+,28+,29+,30+,31+,32-,33-,34+,35-,36+,37+,38-,39-,40+,41-,42-,43-,46-,47-,48+,50-,51+,52+,53+,54-/m0/s1

Molecular Formula	C54H84O23
Molar Mass	1101.23
Density	1.45±0.1 g/cm3 (20 ºC 760 Torr)
Melting Point	197.3-199°C
Boling Point	1111.9±65.0 °C(Predicted)
Specific Rotation(α)	(MeOH)-19.4
Flash Point	305.474°C
Solubility	Soluble in water and methanol, soluble in ethanol and butanol, insoluble in chloroform and acetic acid.
Vapor Presure	0mmHg at 25°C
Appearance	White powder
pKa	2.63±0.70(Predicted)
Storage Condition	2-8℃
Sensitive	Easily absorbing moisture
Refractive Index	1.624
Physical and Chemical Properties
In vivo study	Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibit the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest. Escin IIb (10-50 mg/kg; p.o.) potently inhibits ethanol-induced gastric mucosal lesions. Animal Model: Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats) Dosage: P.o. Administration: 10-50 mg/kg Result: Showed a potent protective effect against ethanol-induced gastric lesions in rats.

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