AKOS 236-34
Osthole
CAS: 484-12-8
Molecular Formula: C15H16O3
AKOS 236-34 - Names and Identifiers
| Name | Osthole |
| Synonyms | OSTHOL osthol Osthole OSTHOLE AKOS 236-34 Chuanxiongzine Cnidium lactone(OSTHOLE ) Common Cnidium Fruit Extract 7-Methoxy-8-isopentenylcoumarin 7-methoxy-8-(3-methyl-2-butenyl)-coumari 7-Methoxy-8-(3-methyl-2-butenyl)-coumarin 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one 7-Methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one |
| CAS | 484-12-8 |
| EINECS | 1532714-185-1 |
| InChI | InChI=1/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3 |
| InChIKey | MBRLOUHOWLUMFF-UHFFFAOYSA-N |
AKOS 236-34 - Physico-chemical Properties
| Molecular Formula | C15H16O3 |
| Molar Mass | 244.29 |
| Density | 1.1263 (rough estimate) |
| Melting Point | 83-84°C |
| Boling Point | 347.2°C (rough estimate) |
| Flash Point | 167.6°C |
| Water Solubility | 12mg/L(25 ºC) |
| Solubility | Soluble in alkali solution, methanol, ethanol, chloroform, acetone, ethyl acetate and boiling petroleum ether, etc., insoluble in water and petroleum ether. |
| Vapor Presure | 1.67E-06mmHg at 25°C |
| Appearance | White needle crystalline powder |
| Color | white |
| Maximum wavelength(λmax) | ['322nm(MeOH)(lit.)'] |
| Merck | 14,6895 |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.5570 (estimate) |
| MDL | MFCD00076049 |
| Physical and Chemical Properties | Soluble in alkali solution, methanol, ethanol, chloroform, acetone, ethyl acetate and boiling petroleum ether, insoluble in water and petroleum ether. Fruit from Cnidium monnieric(L.)Cuss. |
AKOS 236-34 - Risk and Safety
| WGK Germany | 3 |
| RTECS | GN7700000 |
| HS Code | 29322090 |
AKOS 236-34 - Reference
| Reference Show more | 1. Li Wencao, 2], Gu Youfang, etc. Effects of osthole on ultrastructure of Giardia lamblia in vitro [J]. Chinese Journal of Parasitology and parasitic diseases, 2014, 32(3):19-242. 2. Liu Chang, Wu Na, Tian Tian, etc. Effects of osthole on Giardia lamblia isolated from dogs in vitro [J]. Chinese Journal of pathogenic Biology, 2013, 008(011):1014-1016. 3. Wang Qing, Zhang Yun, Mao Hongjiao, et al. Effect of osthole on TCP granule-induced skull lysis in mice [J]. Chinese Journal of pathophysiology, 2015, 31(12):2265-2270. 4. Yang Ninghui, Fu Jinfang, Cao Lingli. Optimization of preparation technology and in vitro release behavior of osthole osmotic pump controlled release tablets [J]. Chinese traditional medicines, 2018, 040(009):1954-1958. 5. High school Cheng Yan. Studies on the enhancement of transdermal absorption of osthole and guaioside by wintergreen oil [J]. Chinese Journal of Traditional Chinese Medicine, 2017 042(007):1338-1343. 6. Xuelian Wang, Minmin Li, Hu Junhua, et al. Inhibitory effects of 18 coumarins on Colletotrichum gloeosporioides in Citrus [J]. Southern China fruit trees, 2013, 42(004):73-74. 7. Zhang Shan. Effects of osthole on inflammatory factors and behavior in rats with chronic unpredictable stress depression [J]. Clinical research of traditional Chinese medicine, 2020,12(25):25-28. 8. Peng Wen-hui, Zhao Xi-Juan, Chen Xi, Zhang Yao-Hai, Wang Cheng-Qiu, Zhao Qi-Yang, jiao bi-Ning. Rapid screening of bioactive components in lemon fruit by ultra performance liquid chromatography-quadrupole-Time of Flight high resolution mass spectrometry [J]. Food and Fermentation Industry, 2021,47(04):222-230 235-237. 9. Huang, Wei, et al. "Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo." Biopharmaceutics & drug disposition 41.1-2 (2020): 64-71.https:// doi.org/10.1002/bdd.2214 10. Huang, Wei, et al. "Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo." Biopharmaceutics & drug disposition 41.1-2 (2020): 64-71.https://doi.org/10.1002/bdd.2214 11. Waqas M, Wang Y, Li A, Qamar H, Yao W, Tong X, Zhang J, Iqbal M, Mehmood K, Li J. Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens. Antioxidants. 2019; 8(9):330. https://do 12. Jing Liang, Jianlong Zhou, Youqin Xu, Xiaofei Huang, Xuefei Wang, Wenhua Huang, Hui Li, Osthole inhibits ovarian carcinoma cells through LC3-mediated autophagy and GSDME-dependent pyroptosis except for apoptosis European Journal of Pharmacology, Volume 87 13. Chen, Xi, et al. "Antipruritic effect of ethyl acetate extract from fructus cnidii in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis." Evidence-Based Complementary and Alternative Medicine 2020 (2020).https://doi.org/10.1155/2020/6981386 14. Yang, Yan-Fang, Lei Zhang, and Xiu-Wei Yang. "Distribution assessments of coumarins from Angelicae Pubescentis Radix in rat cerebrospinal fluid and brain by Liquid Chromatography Tandem Mass Spectrometry analysis." Molecules 23.1 (2018): 225.https://doi.or 15. [IF=7.514] Gui-Jie Li et al."Determination of citrus juice coumarins, furanocoumarins and methoxylated flavones using solid phase extraction and HPLC with photodiode array and fluorescence detection."Food Chem. 2019 Jan;271:29 16. [IF=4.411] Liang Yang et al."New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum."Molecules. 2016 Apr;21(4):468 17. [IF=3.246] Sun Chaojie et al."Preparation and Pharmacokinetics Evaluation of Solid Self-Microemulsifying Drug Delivery System (S-SMEDDS) of Osthole."Aaps Pharmscitech. 2018 Jul;19(5):2301-2310 18. [IF=5.753] Liu Man et al."Constructing a Core Collection of the Medicinal Plant Angelica biserrata Using Genetic and Metabolic Data."Front Plant Sci. 2020 Dec;0:2099 19. [IF=4.831] Ruili Li et al."Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway."Aging-Us. 2020 May 15; 12(9): 7945-7962 20. [IF=4.52] Muhammad Waqas et al."Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens."Antioxidants-Basel. 2019 Sep;8(9):330 21. [IF=4.162] Guijie Li et al."Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil."Drug Des Dev Ther. 2021; 15: 937-947 22. [IF=3.263] Jing Liang et al."Osthole inhibits ovarian carcinoma cells through LC3-mediated autophagy and GSDME-dependent pyroptosis except for apoptosis."Eur J Pharmacol. 2020 May;874:172990 23. [IF=2.629] Yang Niuniu et al."Desensitization of TRPV1 Involved in the Antipruritic Effect of Osthole on Histamine-Induced Scratching Behavior in Mice."Evid-Based Compl Alt. 2021;2021:4012812 24. [IF=1.813] Chen Xi et al."Antipruritic Effect of Ethyl Acetate Extract from Fructus cnidii in Mice with 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis."Evid-Based Compl Alt. 2020;2020:6981386 25. [IF=1.663] Wei Huang et al."Effects of osthol on activity, mRNA and protein expression of Cyp3a in rats in vivo."Biopharm Drug Dispos. 2020 Feb;41(1-2):64-71 26. [IF=4.566] Li Ruili et al."Integrated 16S rRNA Gene Sequencing and Metabolomics Analysis to Investigate the Important Role of Osthole on Gut Microbiota and Serum Metabolites in Neuropathic Pain Mice."Front Physiol. 2022 Feb;0:35 |
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