Name | N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxoethyl]acetamide |
Synonyms | 2-Acetamido-3-hydroxy-4''-nitroacetophenone α-Acetylamino-β-hydroxy-4'-nitropropiophenone 4'-Nitro-α-(acetylamino)-β-hydroxypropiophenone 4-nitro-alpha-acetylamino-beta-hydroxypropiophenone N-[2-keto-1-methylol-2-(4-nitrophenyl)ethyl]acetamide N-[3-hydroxy-1-(4-nitrophenyl)-1-oxopropan-2-yl]acetamide ALPHA-(ACETAMIDO)-BETA-(HYDROXYETHYL)-P-NITROPHENYLKETONE N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxoethyl]acetamide |
CAS | 3123-13-5 |
EINECS | 221-503-3 |
Molecular Formula | C11H12N2O5 |
Molar Mass | 252.22 |
Use | chloramphenicol intermediate. |
production method | bromination of p-nitroacetophenone with bromine to form p-nitro-α-bromoacetophenone, the salt is then formed with hexamethylenetetramine to give P-nitro-α-bromoacetophenone hexamethylenetetramine salt. The latter was hydrolyzed with hydrochloric acid to obtain p-nitro-α-aminoacetophenone hydrochloride, and then acylated with acetic anhydride and added with formaldehyde and methanol (hydroxymethylation) to obtain the product. |