Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-
diloxanide
CAS: 579-38-4
Molecular Formula: C9H9Cl2NO2
Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl- - Names and Identifiers
| Name | diloxanide |
| Synonyms | RD 3803 Entamide Ame-boots Diloxanid Amebamida Diloxanide diloxanide Diloxanida Diloxanidum BRN 2840273 UNII-89134SCM7M Diloxanidum [INN-Latin] Diloxanida [INN-Spanish] 2,2-Dichlor-4'-hydroxy-N-methylacetanilid α,α-Dichloro-4'-hydroxy-N-methylacetanilide 2,2-Dichloro-4'-hydroxy-N-methylacetanilide Acetanilide, 2,2-dichloro-4'-hydroxy-N-methyl- 2,2-Dichlor-4'-hydroxy-N-methylacetanilid [IUPAC] 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-acetamide 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-ethanamide Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl- |
| CAS | 579-38-4 |
| EINECS | 2094394 |
| InChI | InChI=1/C9H9Cl2NO2/c1-12(9(14)8(10)11)6-2-4-7(13)5-3-6/h2-5,8,13H,1H3 |
Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl- - Physico-chemical Properties
| Molecular Formula | C9H9Cl2NO2 |
| Molar Mass | 234.081 |
| Density | 1.439±0.06 g/cm3(Predicted) |
| Melting Point | 175° |
| Boling Point | 356.2±42.0 °C(Predicted) |
| Flash Point | 169.2°C |
| Vapor Presure | 1.45E-05mmHg at 25°C |
| pKa | 9.95±0.15(Predicted) |
| Refractive Index | 1.615 |
| In vivo study | Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate.Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats. |
Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl- - Reference Information
| biological activity | diloxide is an antigenic agent, it can be used for histological study of asymptomatic intestinal Amebiasis caused by Entamoeba or other protozoa. Diloxanide is an active Lumina anti-amoebic agent derived in the gastrointestinal tract from the hydrolysis of its prodrug, diclorotate furoate (HY-B1147). |
Last Update：2024-04-10 22:29:15
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