Molecular Formula | C19H19N5O |
Molar Mass | 333.39 |
Density | 1.20±0.1 g/cm3(Predicted) |
Melting Point | >164°C (dec.) |
Boling Point | 469.4±45.0 °C(Predicted) |
Solubility | DMSO: ≥20mg/mL |
Appearance | powder |
Color | orange-brown |
pKa | 12.98±0.70(Predicted) |
Storage Condition | 2-8°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
In vitro study | CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation. |
In vivo study | CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | 22 - Do not breathe dust. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.999 ml | 14.997 ml | 29.995 ml |
5 mM | 0.6 ml | 2.999 ml | 5.999 ml |
10 mM | 0.3 ml | 1.5 ml | 2.999 ml |
5 mM | 0.06 ml | 0.3 ml | 0.6 ml |
biological activity | CH-223191 is a potent antagonist of a specific aryl hydrocarbon receptor (AhR) with an IC50 of 30 nM. |