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Atorvastatin free ACID

Atorvastatin

CAS: 134523-00-5;110862-48-1

Molecular Formula: C33H35FN2O5

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Atorvastatin free ACID - Names and Identifiers

Name Atorvastatin
Synonyms Atrovastitne
Atorvastatin
Atorvastatin Acid
ATORVASTATIN(LIPITOR)
Atorvastatin free ACID
1H-PYRROLE-1-HEPTANOIC ACID
Atorvastatin (Subject to Patent free)
(bR,dR)-2-(p-Fluorophenyl)-β,δ-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid
(3S,5S)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid
(3S,5S)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
(3R,5R)-2-(4-Fluorophenyl)-3,5-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
calcium bis{(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate}
1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, (βR,δR)-rel-
CAS 134523-00-5
110862-48-1
EINECS 806-698-0
InChI InChI=1/C33H34FNO5.Ca/c1-21(2)31-30(33(40)24-11-7-4-8-12-24)29(22-9-5-3-6-10-22)32(23-13-15-25(34)16-14-23)35(31)18-17-26(36)19-27(37)20-28(38)39;/h3-16,21,26-27,36-37H,17-20H2,1-2H3,(H,38,39);/q;+2/p-1/t26-,27-;/m1./s1

Atorvastatin free ACID - Physico-chemical Properties

Molecular FormulaC33H35FN2O5
Molar Mass558.65
Density1.23±0.1 g/cm3(Predicted)
Melting Point176-178°C
Boling Point722.2±60.0 °C(Predicted)
pKapKa 4.46(H2O t=30 Iuncontrolled) (Uncertain)
Storage Condition2-8°C
Physical and Chemical PropertiesMelting point 176-178°C
UseUsed as hypolipidemic drug

Atorvastatin free ACID - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
HS Code35040000

Atorvastatin free ACID - Preparation Method

Open Data Verified Data

2-(4 fluorophenyl)-p carbonyl 8 hydroxy -5-(1-methyl ethyl)-3-phenyl 4 [(phenyl amino) carbonyl]-1H-pyrrole-1-heptanoic acid tert-butyl alcohol is reduced with triethylboron and sodium borohydride in methanol, and the product is hydrolyzed to obtain sodium atovastatin. Atovastatin is available via acidification. Atopastatin was refluxed in toluene to give atopastatin lactone.

Last Update：2024-01-02 23:10:35

Atorvastatin free ACID - Use

Open Data Verified Data

Pfizer co-launched with the company Parke-Davis and was launched in 19, 9, 7. Hypolipidemic drug. Can significantly reduce low density lipoprotein cholesterol and triglyceride levels. Can inhibit the activity of HMG-CoA reductase, thus reducing cholesterol synthesis.

Last Update：2022-01-01 09:11:01
Atorvastatin free ACID
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Product Name: Atorvastatin Request for quotation
CAS: 134523-00-5
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Atorvastatin free ACID
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