Azilsartan Medoxomil
Azilsartan medoxomil
CAS: 863031-21-4
Molecular Formula: C30H24N4O8
Azilsartan Medoxomil - Names and Identifiers
| Name | Azilsartan medoxomil |
| Synonyms | CS-306 TAK 491 Azilsaran medoxomil Azilsartan Medoxomil Azilsartan medoxomil 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzim (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-+oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-, (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester |
| CAS | 863031-21-4 |
| EINECS | 1308068-626-2 |
| InChI | InChI:1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36) |
Azilsartan Medoxomil - Physico-chemical Properties
| Molecular Formula | C30H24N4O8 |
| Molar Mass | 568.53 |
| Density | 1.45 |
| Melting Point | 160-161oC |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| Appearance | Solid |
| Color | White to Light Beige |
| pKa | 6.99±0.20(Predicted) |
| Storage Condition | Refrigerator |
| In vitro study | Azilsartan medoxomil is a prodrug that can be rapidly converted to the active moiety in the intestine and plasma by ester hydrolysis, azilsartan (TAK-536). In vascular smooth muscle and adrenal glands, Azilsartan selectively blocks the binding of angiotensin II to AT1 (type 1 angiotensin II) receptors, thereby promoting vasodilation and reducing the effect of aldosterone. Azilsartan is a highly selective antagonist of the AT1 receptor with an IC50 of 2.6 nM, has more than 10,000-fold affinity for the AT1 receptor as compared to the AT2 receptor, and has no affinity for other cardiac receptors or ion channels. The inhibitory effect of Azilsartan was still present after washing with free compound (IC50 value of 7.4 nM). Azilsartan also inhibited angiotensin II-induced accumulation of inositol -1-phosphate (IP1) at the cellular level with an IC50 value of 9.2 nM, and this effect is resistant to washing (IC50 value of 81.3 nM). Azilsartan medoxomil is a prodrug that can be rapidly converted to the active moiety in the intestine and plasma by ester hydrolysis, azilsartan (TAK-536). In vascular smooth muscle and adrenal glands, Azilsartan selectively blocks the binding of angiotensin II to AT1 (type 1 angiotensin II) receptors, thereby promoting vasodilation and reducing the effect of aldosterone. Azilsartan is a highly selective antagonist of the AT1 receptor with an IC50 of 2.6 nM, has more than 10,000-fold affinity for the AT1 receptor as compared to the AT2 receptor, and has no affinity for other cardiac receptors or ion channels. The inhibitory effect of Azilsartan was still present after washing with free compound (IC50 value of 7.4 nM). Azilsartan also inhibited angiotensin II-induced accumulation of inositol -1-phosphate (IP1) at the cellular level with an IC50 value of 9.2 nM, and this effect is resistant to washing (IC50 value of 81.3 nM). |
Azilsartan Medoxomil - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.759 ml | 8.795 ml | 17.589 ml |
| 5 mM | 0.352 ml | 1.759 ml | 3.518 ml |
| 10 mM | 0.176 ml | 0.879 ml | 1.759 ml |
| 5 mM | 0.035 ml | 0.176 ml | 0.352 ml |
Last Update：2024-01-02 23:10:35
Azilsartan Medoxomil - Introduction
Azilsartan medoxomil is an organic compound, often referred to simply as "DMF".
Nature:
-Appearance: DMF is a colorless to slightly yellow liquid.
-Solubility: DMF has good solubility and is soluble in water and most organic solvents.
-Melting point:-60°C
-Boiling Point: 153-157°C
-Density: 1.128 g/ml
Use:
- DMF is often used as a solvent in organic synthesis and can dissolve many organic compounds.
-It is also an important reagent and catalyst solvent for many chemical reactions.
Preparation Method:
DMF is usually prepared by the reaction of methanol and formic acid, and the final product is obtained through a series of reaction steps.
Safety Information:
- DMF has carcinogenic potential, so pay attention to protective measures when using it.
-This compound is irritating and corrosive to the skin and eyes and should be avoided.
-Use should follow safe operating procedures and operate in a well-ventilated environment.
-As a toxic chemical, DMF must be stored and handled in accordance with relevant regulations.
Nature:
-Appearance: DMF is a colorless to slightly yellow liquid.
-Solubility: DMF has good solubility and is soluble in water and most organic solvents.
-Melting point:-60°C
-Boiling Point: 153-157°C
-Density: 1.128 g/ml
Use:
- DMF is often used as a solvent in organic synthesis and can dissolve many organic compounds.
-It is also an important reagent and catalyst solvent for many chemical reactions.
Preparation Method:
DMF is usually prepared by the reaction of methanol and formic acid, and the final product is obtained through a series of reaction steps.
Safety Information:
- DMF has carcinogenic potential, so pay attention to protective measures when using it.
-This compound is irritating and corrosive to the skin and eyes and should be avoided.
-Use should follow safe operating procedures and operate in a well-ventilated environment.
-As a toxic chemical, DMF must be stored and handled in accordance with relevant regulations.
Last Update：2024-04-09 20:49:11
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Product Name: Azilsartan Impurity 50 Visit Supplier Webpage Request for quotationCAS: 863031-21-4
Tel: 0714-3999186
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Mobile: 86+15671228036
QQ: 2853786052
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Product Name: Azilsartan Medoxomil Visit Supplier Webpage Request for quotation
CAS: 863031-21-4
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 863031-21-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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