BIS(2-HYDROXYETHYL THIO)METHANE
3,5-Dithioheptane-1,7-diol
CAS: 44860-68-6
Molecular Formula: C5H12O2S2
BIS(2-HYDROXYETHYL THIO)METHANE - Names and Identifiers
| Name | 3,5-Dithioheptane-1,7-diol |
| Synonyms | NSC 2875 AI3-18188 3,5-DITHIA-1,7-HEPTA 3,5-Dithiaheptane-1,7-diol 3,5-Dithioheptane-1,7-diol 3,5-DITHIA-1,7-HEPTANEDIOL 3,5-Dithia-1,7-Heptanediol Bis(2-hydroxyethylthio)methane BIS(2-HYDROXYETHYL THIO)METHANE 2,2'-(methylenebis(thio))bis-ethano 2,2'-(Methylenebis(thio))bisethanol Ethanol, 2,2'-(methylenebis(thio))bis- 2,2'-(methanediyldisulfanediyl)diethanol 2-[(2-hydroxyethylthio)methylthio]ethanol 2,2'-(Methylenebis(sulfanediyl))diethanol 2-(2-HYDROXY-ETHYLSULFANYLMETHYLSULFANYL)-ETHANOL |
| CAS | 44860-68-6 |
| EINECS | 256-166-1 |
| InChI | InChI=1/C5H12O2S2/c6-1-3-8-5-9-4-2-7/h6-7H,1-5H2 |
BIS(2-HYDROXYETHYL THIO)METHANE - Physico-chemical Properties
| Molecular Formula | C5H12O2S2 |
| Molar Mass | 168.28 |
| Density | 1.255g/cm3 |
| Boling Point | 357.2°C at 760 mmHg |
| Flash Point | 173.7°C |
| Vapor Presure | 1.54E-06mmHg at 25°C |
| Refractive Index | 1.574 |
BIS(2-HYDROXYETHYL THIO)METHANE - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| application | 3, 5-dithiaza-1, 7-heptanediol can be used as an intermediate in pharmaceutical synthesis and an intermediate in organic synthesis, mainly used in laboratory research and development and chemical pharmaceutical synthesis. |
| preparation | 3,5-disulfide -1,7-heptanediol is prepared as follows: sodium hydroxide (2.00g,50mmol) is dissolved in water (4ml), and 2-mercaptoethanol (3.91g,50mmol) is added dropwise at 20 ℃ in nitrogen atmosphere. In addition, a quaternary ammonium salt phase transfer catalyst dissolved in dichloromethane (2.13g,25mmol) (trade name: "aliquot336", manufactured from ALDRICH (0.10g,0.25mmol)) was added dropwise to it. After that, the mixture was stirred at 25°C for 24 hours. After the reaction, 10ml of dichloromethane was added to the reaction solution, and the water layer except the separated upper layer was concentrated under reduced pressure to obtain 3.50g of colorless oil. Quantification was carried out by gas chromatography ("GC-14B" made by Shimadzu), and the purity of 3, 5-dithiaza-1, 7-heptanediol was 85%, and the yield was 71% (2-mercaptoethanol standard). on the other hand, 10ml of dichloromethane is added to the previously separated water layer, and concentrated hydrochloric acid is added to adjust the pH to 3, and the separated organic layer is also quantified by gas chromatography ("GC-14B" made by ShimadzuCorporation). Containing 0.30 g3, 5-dithiaze-1, 7-heptanediol, the yield was 7% (based on 2-mercaptoethanol). First, 3.60g of oil containing 85% 3, 5-dithiaza-1, 7-heptanediol was obtained by silica gel column chromatography (expansion solvent; n-hexane/ethyl acetate = 1/1-0/1). 1 (volume ratio)) to obtain 2.80 g3, 5-dithia-1-7-heptanediol, which is a colorless oil (based on the separation yield of 2-mercaptoethanol; 67%). |
Last Update：2024-04-10 22:29:15
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