BIX 01294
BIX 01294 Trihydrochloride
CAS: 1392399-03-9
Molecular Formula: C28H41Cl3N6O2
BIX 01294 - Names and Identifiers
BIX 01294 - Physico-chemical Properties
| Molecular Formula | C28H41Cl3N6O2 |
| Molar Mass | 600.02314 |
| Solubility | H2O: >20mg/mL |
| Appearance | powder |
| Color | white |
| Storage Condition | Inert atmosphere,2-8°C |
| In vitro study | BIX01294 is a selective G9a histone methyltransferase inhibitor that does not affect SUV39H1(H320R) and PRMT1 over the range of concentrations tested. BIX-01294 specifically inhibits G9a (H3K9me2) and, to a lesser extent, the closely related GLP enzymes (mainly H3K9me3), acting on G9a and GLP, the IC50 values were 1.7 μm and 38 μm, respectively. BIX-01294 inhibited G9a in a non-competitive manner with SAM. BIX-01294 (4.1 μm) reduced H3K9me2 levels by acting on wild-type ES cells, mouse embryonic fibroblasts, and HeLa cells, but not G9a deficient stem cells. BIX-01294 is an inhibitor of the transient modulation of the valuable chromosome H3K9me2. BIX-01294 H3K9me2 was reduced on some G9a targeted genes, including Bim1 and serac1. BIX01294 reexpresses HIV-1 Virus from latently infected cells such as ACH-2 and om101. BIX01294 is a selective G9a histone methyltransferase inhibitor that does not affect SUV39H1(H320R) and PRMT1 in the experimental concentration range. BIX-01294 specifically inhibits G9a (H3K9me2) and, to a lesser extent, the closely related GLP enzymes (mainly H3K9me3), acting on G9a and GLP, the IC50 values were 1.7 μm and 38 μm, respectively. BIX-01294 inhibited G9a in a non-competitive manner with SAM. BIX-01294 (4.1 μm) reduced H3K9me2 levels by acting on wild-type ES cells, mouse embryonic fibroblasts, and HeLa cells, but not G9a deficient stem cells. BIX-01294 is an inhibitor of the transient modulation of the valuable chromosome H3K9me2. BIX-01294 H3K9me2 was reduced on some G9a targeted genes, including Bim1 and serac1. BIX01294 reexpresses HIV-1 Virus from latently infected cells such as ACH-2 and om101. |
BIX 01294 - Risk and Safety
| WGK Germany | 3 |
BIX 01294 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.667 ml | 8.333 ml | 16.666 ml |
| 5 mM | 0.333 ml | 1.667 ml | 3.333 ml |
| 10 mM | 0.167 ml | 0.833 ml | 1.667 ml |
| 5 mM | 0.033 ml | 0.167 ml | 0.333 ml |
Last Update：2024-01-02 23:10:35
BIX 01294 - Introduction
BIX 01294 Trihydrochloride is a chemical substance whose chemical name is 2-(1h-isoxazol-1-yl)-4,6-diamidinopyrrole.
BIX 01294 Trihydrochloride is widely used in the biomedical field, the most important of which is as a histone methyltransferase inhibitor. It can inhibit the acetyl transferase P300/CBP binding to histones, thereby changing gene expression, affecting the physiological and pathological processes of cells.
The method of preparing BIX 01294 Trihydrochloride is generally chemical synthesis. Specifically, it can be synthesized by multi-step reaction, but the synthesis process is more complex and requires certain chemical expertise and experimental techniques.
Regarding the safety information of BIX 01294 Trihydrochloride, it is an organic compound, so certain safety measures need to be followed when using and handling. Direct contact with skin and inhalation of vapors should be avoided, and appropriate protective gloves and breathing apparatus should be worn. If ingested or inhaled by mistake, please seek medical help and provide relevant safety instructions to the doctor.
BIX 01294 Trihydrochloride is widely used in the biomedical field, the most important of which is as a histone methyltransferase inhibitor. It can inhibit the acetyl transferase P300/CBP binding to histones, thereby changing gene expression, affecting the physiological and pathological processes of cells.
The method of preparing BIX 01294 Trihydrochloride is generally chemical synthesis. Specifically, it can be synthesized by multi-step reaction, but the synthesis process is more complex and requires certain chemical expertise and experimental techniques.
Regarding the safety information of BIX 01294 Trihydrochloride, it is an organic compound, so certain safety measures need to be followed when using and handling. Direct contact with skin and inhalation of vapors should be avoided, and appropriate protective gloves and breathing apparatus should be worn. If ingested or inhaled by mistake, please seek medical help and provide relevant safety instructions to the doctor.
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: BIX 01294 Trihydrochloride Visit Supplier Webpage Request for quotationCAS: 1392399-03-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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