BLARCAMESINE HYDROCHLORIDE, AVEX-73 HYDROCHLORIDE, AE-37 HYDROCHLORIDE
Anavex 2-73
CAS: 195615-84-0
Molecular Formula: C19H24ClNO
BLARCAMESINE HYDROCHLORIDE, AVEX-73 HYDROCHLORIDE, AE-37 HYDROCHLORIDE - Names and Identifiers
BLARCAMESINE HYDROCHLORIDE, AVEX-73 HYDROCHLORIDE, AE-37 HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C19H24ClNO |
| Molar Mass | 317.86 |
| Melting Point | 165 - 168°C |
| Solubility | DMSO : 25 mg/mL (78.65 mM; Need ultrasonic) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
| In vivo study | The pre-administration of Blarcamesine (ANAVEX2-73) leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ 25-35 -induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser 9 phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ 25-35 -induced increase in Aβ 1-42 content, with a significant effect at the highest dose tested. |
BLARCAMESINE HYDROCHLORIDE, AVEX-73 HYDROCHLORIDE, AE-37 HYDROCHLORIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.146 ml | 15.731 ml | 31.461 ml |
| 5 mM | 0.629 ml | 3.146 ml | 6.292 ml |
| 10 mM | 0.315 ml | 1.573 ml | 3.146 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.629 ml |
Last Update：2024-01-02 23:10:35
BLARCAMESINE HYDROCHLORIDE, AVEX-73 HYDROCHLORIDE, AE-37 HYDROCHLORIDE - Reference Information
| biological activity | Anavex 2-73 (Blarcamesine, AVex-73, AE-37) is an amino tetrahydrofuran derivative, it is also an agonist of a mixed muscarinic and sigma-1/p1 Receptor with an IC50 value of 0.86 μm. |
| Target | Value |
| muscarinic () | |
| sigma-1 receptor (Cell-free assay) | 0.86 μM |
Last Update：2024-04-10 22:29:15
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CAS: 195615-84-0
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CAS: 195615-84-0
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