BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide
BRD73954
CAS: 1440209-96-0
Molecular Formula: C16H16N2O3
BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide - Names and Identifiers
BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide - Physico-chemical Properties
| Molecular Formula | C16H16N2O3 |
| Molar Mass | 284.31 |
| Density | 1.245±0.06 g/cm3(Predicted) |
| Melting Point | 172-175oC |
| Solubility | DMSO: ≥ 35 mg/mL |
| Appearance | Solid |
| Color | Off-White |
| pKa | 8.56±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation. |
BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.517 ml | 17.586 ml | 35.173 ml |
| 5 mM | 0.703 ml | 3.517 ml | 7.035 ml |
| 10 mM | 0.352 ml | 1.759 ml | 3.517 ml |
| 5 mM | 0.07 ml | 0.352 ml | 0.703 ml |
Last Update：2024-01-02 23:10:35
BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide - Reference Information
| trait | BRD73954 was white to off-white solid in appearance. |
| Use | BRD73954 is a potent small molecule inhibitor of HDAC6 and hdac8. |
| biological activity | BRD73954 is a potent and selective HDAC inhibitor, the IC50 for HDAC6 and HDAC8 were 36 nM and 120 nM, respectively. |
Last Update：2024-04-09 20:45:29
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Product Name: BRD73954 Visit Supplier Webpage Request for quotationCAS: 1440209-96-0
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Mobile: 18021002903
QQ: 3008007409
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