BT 11
BT-11
CAS: 1912399-75-7
Molecular Formula: C30H24N8O2
BT 11 - Names and Identifiers
| Name | BT-11 |
| Synonyms | BT11 BT-11 BT 11 Omilancor Methanone, 1,1'-(1,4-piperazinediyl)bis[1-[6-(1H-benzimidazol-2-yl)-2-pyridinyl]- [4-[6-(1~{H}-benzimidazol-2-yl)pyridine-2-carbonyl]piperazin-1-yl]-[6-(1~{H}-benzimidazol-2-yl)pyridin-2-yl]methanone |
| CAS | 1912399-75-7 |
BT 11 - Physico-chemical Properties
| Molecular Formula | C30H24N8O2 |
| Molar Mass | 528.56 |
| Solubility | DMSO: ≥30 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | In splenocytes isolated from WT or LANCL2 −/− mice, treatment of increasing concentrations of BT-11 and detection of intracellular cAMP levels: BT-11 can stimulate cAMP production by activating the LANCL2 pathway. |
| In vivo study | Oral BT-11 of 8 mg/kg/day in mice can slow down the colitis. In the drug safety test in rats, oral administration of high-concentration BT-11 has good safety (detection concentration up to 1000 mg/kg/day). In a mouse model of colitis induced by dextran sulfate sodium, oral administration of BT-11 upregulated the expression level of IL-10 and downregulated the expression of TNF-α mRNA. BT-11 can also upregulate the expression of LANCL2 in the gastrointestinal tract. |
BT 11 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.892 ml | 9.46 ml | 18.919 ml |
| 5 mM | 0.378 ml | 1.892 ml | 3.784 ml |
| 10 mM | 0.189 ml | 0.946 ml | 1.892 ml |
| 5 mM | 0.038 ml | 0.189 ml | 0.378 ml |
Last Update：2024-01-02 23:10:35
BT 11 - Reference Information
| biological activity | BT-11 is an orally active, C- like 2 (LANCL2) the combined compound, with a Kd value of 7.7 μm, is useful in the treatment of inflammatory bowel disease. |
| Target | Value |
Last Update：2024-04-10 22:29:15
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Product Name: BT11 Visit Supplier Webpage Request for quotationCAS: 1912399-75-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: BT-11 Visit Supplier Webpage Request for quotationCAS: 1912399-75-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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