Bayer 77049
Quinalphos
CAS: 13593-03-8
Molecular Formula: C12H15N2O3PS
Bayer 77049 - Names and Identifiers
| Name | Quinalphos |
| Synonyms | 6538 6538e bay5821 bay77049 BAY 77049 Quinalphos chinalphos bayer77049 Bayer 77049 O,O-diethyl O-2-quinoxalinyl phosphorothioate O,O-diethyl O-quinoxalin-2-yl phosphorothioate |
| CAS | 13593-03-8 |
| EINECS | 237-031-6 |
| InChI | InChI=1/C12H15N2O3PS/c1-3-15-18(19,16-4-2)17-12-9-13-10-7-5-6-8-11(10)14-12/h5-9H,3-4H2,1-2H3 |
Bayer 77049 - Physico-chemical Properties
| Molecular Formula | C12H15N2O3PS |
| Molar Mass | 298.3 |
| Density | 1.306±0.06 g/cm3(Predicted) |
| Melting Point | 31.5°C |
| Boling Point | 142 °C |
| Flash Point | 2°C |
| Water Solubility | 17.8 mg l-1 (22-23 °C) |
| Vapor Presure | 3.46×10-4 Pa (20 °C) |
| Appearance | Crystalline |
| BRN | 754823 |
| pKa | -1.05±0.30(Predicted) |
| Storage Condition | APPROX 4°C |
| Refractive Index | 1.603 |
| Physical and Chemical Properties | Pure white odorless crystals. m. P. 31-32 °c, B. p.142 °c/3.999 x 10-2Pa (decomposition), relative density 1.235(20 °c), refractive index n25D1.5624, vapor pressure 3.3466 x 10-4Pa (20 °c). Soluble in benzene, toluene, xylene, alcohol, ether, acetone, acetonitrile, ethyl acetate and other organic solvents, slightly soluble in petroleum ether, solubility in water is 22mg/L (normal temperature). Acidic conditions are easy to hydrolyze and decompose at 120. |
| Use | For contact, stomach poison and penetration of insecticides and acaricides, for the control of Lepidoptera, pink bollworm, cotton bollworm, Red Spider and vegetables on the cabbage insects |
Bayer 77049 - Risk and Safety
| Risk Codes | R21 - Harmful in contact with skin R25 - Toxic if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 2783 |
| WGK Germany | 3 |
| RTECS | TF6125000 |
| HS Code | 29339900 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
Bayer 77049 - Upstream Downstream Industry
Bayer 77049 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| quetiapine pesticide | common name in English quinalphos other names ecalyx quinhphosphorus toxicity: quinhphosphorus is a toxic insecticide. No irritation to the skin and eyes, little accumulation in animals, no chronic toxicity, no carcinogenic, teratogenic, mutagenic effect. Dosage Form: 25% quetiapine EC, 25% ECCAS EC and 5% ECCAS granules. Characteristics of quetiapine with insecticidal, acaricidal effect, with stomach poison and killing effect, no absorption and fumigation performance, good permeability in plants, there is a certain role of killing eggs, in plants, the degradation rate is fast, and the residual effect period is short. Scope of Application: suitable for rice, cotton, fruit trees, vegetables on a variety of pest control. Method of use 1. Prevention and Control of rice pests quetiapine is a specific drug for the prevention and control of mosquito, with 25% emulsifiable concentrate 150 per mu, 60-1.25 spray on water or 5% granules 1.5. Prevention and Control of Chilo suppressalis, Chilo suppressalis each with 25% Cream 100-130, spray on water 75; Or with 5% granules 1-per mu, evenly sprayed. This dose can be used for the control of rice planthopper and leaf hopper, Rice thrips, rice leaf roller etc. 2. Control of cotton pests cotton aphid per mu with 25% emulsifiable concentrate 50 -- 60 ml, 50kg of water spray. Cotton thrips per mu with 25% emulsifiable concentrate 66-100, 60 kilograms of water spray. Cotton bark insect per mu with emulsifiable concentrate 133 -- 166, 75 kilograms of water spray. 3. Prevention and Control of citrus insect pests citrus leaf occult moth with 25% emulsifiable concentrate 600-750 times liquid control. Orange aphid with 500-750 times liquid control, this dose can also control the scale insect. 4. Prevention and Control of tea tree pests to control the small green leaf cicada, tea geometrid, each mu with 25% cream 150-200, 150-200 liters of water spray. 5. Prevention and Control of vegetable pests control cabbage worm, Spodoptera litura per mu with 25% cream 60-80 ml, 50-60 liters of water spray. Note 1. Do not mix with alkaline substances. 2. The safe use, poisoning symptoms and first aid measures of quetiapine are the same as those of common organic phosphorus. |
| Method for Determination of quetiapine residues in rice and citrus | 1 subject matter and scope of application this standard specifies the determination of quetiapine in rice and citrus by gas chromatography. This standard is applicable to the determination of quetiapine residues in rice and citrus. The minimum detection limit of this method is 5 × 10-9G, 2.5 × 10-9G, and the minimum detectable concentration of 0.03g sample is mg/kg. 2 Principle brown rice and citrus are extracted with acetone and benzene (1 ∶ 1V/V) mixed solvent, purified by liquid-liquid distribution and Sili silica column, it was rinsed with a mixed solvent of acetone and benzene (1: 4V/V) and measured at FPD-GC after volume determination. 3 reagent 3.1 acetone: analytically pure, re-distilled. 3.2 benzene: analytically pure, redistilled. 3.3 anhydrous sodium sulfate: Analytical purity. 3.4 Sili silica (activated 4~5h at 650 C, 3% water). 3.5 quetiapine: purity 99.5%. 4 instrument 4.1 gas chromatograph with flame photometric detector (phosphorus-filter). 4.2 rice rough machine. 4.3 pulverizer. 4.4 oscillator. 4.5 tissue compactor. 4.6 Rotary evaporator. 4.7 microsyringe: 100 μl. 4.8 glass instruments: with piston glass chromatography column, separatory funnel, volumetric flask, with glass plug triangle flask. 5 analysis step 5.1 Sample extraction: weigh 50.0g brown rice (ground powder), or soil 20.0g or 50.0g orange peel (homogenate) or 100g Orange (homogenate), load into 250mL plug triangle flask, add 100ml acetone and benzene (1: 1V/V) mixed solvent (soil plus filter aid), with 100ml benzene shaking for 30min, with sand core funnel Suction filtration. To the residue was added 80ml of the above mixed solvent, which was shaken for 30min, suction filtered, and the filtrates were combined. 5.2 Purification: the above extract was transferred to a 200mL separatory funnel, and sodium sulfate aqueous solution was added. The mixture was shaken for 1min, and the layers were separated at rest. Transfer the lower aqueous phase to another 500ml separatory funnel, extract with 20ml × 2 benzene twice, incorporate benzene solution, dehydrate with anhydrous sodium sulfate, and transfer to a flat-bottomed flask, concentrate to 2-3ml under reduced pressure in a 40 °c water bath. Take a glass chromatography column and load it with 10g silicium silica. Load both the upper and lower ends of the column with 1.5cm thick anhydrous sodium sulfate. The solution was pre-washed with 20ml of benzene, poured into the above concentrate, rinsed with 100ml of a mixed solvent of acetone and benzene (1:4V/V), and collected in a flat-bottomed flask. In 40 deg C water bath under reduced pressure concentration, constant volume 3ml, measurement. |
| Method for Determination of quetiapine residues in rice and citrus continued | 5.3 chromatographic conditions: 5.3.1 column: glass column × 4mm × 1.5m, filled with 3% 0V-101 + OV-210/Chromosorb W 60-80 mesh. 5.3.2 temperature: the column temperature is 230 ℃, the inlet temperature is 250 ℃, and the detector temperature is 250 ℃. 5.3.3 gas flow rate: carrier gas (nitrogen) 50mL/min, hydrogen 65mL/min, air 30mL/min. 5.3.4 retention time under the above conditions, the retention time of quetiapine is 3 '4 ", and the retention time of quinoxyphosphorus is 4 '50 ″. 5.4 determination: qualitative retention time, quantitative external standard method. Standard solutions of 2 × 10-9, 6 × 10-9, 8 × 10-9 and 1 × 10-8g/μL were prepared with quetiapine and quinoxyphosphorus respectively. The working curve is drawn with the peak height as the ordinate and the standard sample amount as the abscissa. Quantification was based on the peak height (or peak area) of the sample. 6 calculation: Where: X-quetiapine residue in sample, mg/kg;B-measured content of sample peak height, μg;V-volume before injection, mL;A -- injection volume, μl; m -- Sample mass, g. Note: citrus fruit residues were calculated. Formula: Whole Fruit residue (mg/kg)= Orange Peel residue x Orange Peel (%) + orange meat residue x Orange meat (%) 7 accuracy and precision: 7.1 accuracy: the recovery rate was more than 0.05 in the range of 0.5 ~ 80% μg/g. 7.2 precision: the coefficient of variation was below 10%. |
| toxicity | Acute oral LD50 in rats was 71mg/kg(137mg/kg), acute percutaneous LD50800 ~ 1750mg/kg, acute inhalation of ld500.71 mg/L. There was no irritation to rabbit eyes and skin. Rats were fed with feed containing 160mg/kg for 90d, and no poisoning was observed. The 2-year feeding dose without effect was 3 mg/kg for rats and 0.5mg/kg for dogs. In the test dose, no carcinogenic, teratogenic, mutagenic effect. Carp LD503 ~ 10mg/L (48h), goldfish ld5010 mg/L (24h). Toxic to bees. |
| Use | broad-spectrum insecticide and acaricide, with gastric poison and contact killing effect, without inhalation and fumigation effect, there is a certain role in the killing of eggs. It has special effects on rice gall midge. During the peak period of adults in middle-late rice fields, it should be applied once every 7-10 days, usually twice, 25% ~ 22.5 of emulsifiable concentrate per hundred square meters each time, 9 ~ 22.5kg of water spray, or with 5% granules 180 ~ 225g spraying, the field must maintain a certain amount of water. Control rice leaf roller, Rice thrips, with 25% emulsifiable concentrate per hundred square meters of 22.5 ~ 30mL of water 7.5 ~ 9kg spray. For the prevention and control of Chilo suppressalis, Chilo suppressalis, Rice planthopper and rice leaf hopper, etc., spray 25% of water with 15-150 of emulsifiable concentrate per hundred square meters, or spread-225g of granules per hundred square meters. Control cotton aphid with 25% emulsifiable concentrate 7.5 ~ 9mL, 7.5kg of water spray. In addition, it can also control cotton thrips, citrus leaf moth, scale insect, small green leaf hopper, tea geometrid and so on. It is an insecticide and acaricide with contact, stomach poison and permeability, and is used to control lepidoptera, pink bollworm, cotton bollworm, Red Spider and cabbage insects on vegetables. It is an organophosphorus insecticide and acaricide, it has the effect of killing and stomach poison, and has a wide insecticidal spectrum, quetiapine is a broad-spectrum organophosphorus insecticide, which has the effect of killing and stomach poison, and has the effect of sucking insect pests on chewers and mouthsticks. It is used for controlling rice stem insects and cotton pests, vegetable aphids, etc. Calibration instruments and devices; Evaluation methods; Working standards; Quality assurance/quality control; Other. |
| production method | preparation of O,O-diethylthiophosphoryl chloride dichlorides are produced by the reaction of trichlorosulfon with excess absolute ethanol, at 25~35 ℃, the residence time is 35min, then it is washed with water and separated into chloride. Then, with the excess of anhydrous ethanol, alkali powder was added, and the reaction temperature was controlled to 0~5 C. When the pH value reached 9~10, the end point of the reaction was reached. The ethyl chloride, O,O-diethyl thiophosphoryl chloride, is obtained after work-up. Foreign use of phosphorus pentasulfide method, by phosphorus pentasulfide and ethanol reaction of diethyl dithiophosphoric acid, then by chlorination of ethyl chloride. The post-treatment process is relatively difficult. Preparation of 2-hydroxyquinoxaline 2-hydroxyquinoxaline was prepared by reaction of O-phenylenediamine with chloroacetic acid. The acid binding agent can be used as ammonium carbonate at 65 C for 1H to obtain 3, 4-dihydro-2-hydroxyquinoxaline in a yield of 92%. Then, in the presence of sodium hydroxide, the reaction was carried out with hydrogen peroxide at 60 ℃ for 5~6h to obtain 2-hydroxyquinoxaline. The total yield of the two steps was 82%. Synthesis of quetiapine 2-hydroxyquinoxaline, ethyl acetate and anhydrous potassium carbonate were successively added into the reactor, heated and stirred, and ethyl chloride was slowly added, add xylene, wash, layer, sampling and analysis. After dexylene, the crude oil content was 86.0% and the yield was 86.3%. with O-phenylenediamine, chloroacetic acid, hydrogen peroxide as raw materials, preparation of intermediate 2-hydroxyquinoxaline, O-diethylthiophosphoryl chloride is condensed in acetonitrile in the presence of potassium carbonate to give quetiapine. Raw material consumption quota: O-phenylenediamine 1200kg/t, chloroacetic acid 1100kg/t, O,O-diethylthiophosphoryl chloride 800kg/t. |
| category | pesticide |
| toxicity grade | highly toxic |
| Acute toxicity | oral-rat LD50: 26 mg/kg; Oral-mouse LD50: 107 mg/kg |
| flammability hazard characteristics | open flame flammable; Thermal decomposition of toxic phosphorus oxide, sulfur oxide, nitrogen oxide gas |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | Sand, dry powder, foam |
Last Update：2024-04-09 21:11:58
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