Benzbromarone Impurity 7 (6-Hydroxy-Benzbromarone)

Benzbromarone Impurity 7 (6-Hydroxy-Benzbromarone) - Names and Identifiers

Name	(3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxybenzofuran-3-yl)methanone
Synonyms	Benzbromarone Impurity 10 BenzbromaroneImpurity7-13C6 BenzbromaroneImpurity7-13C3-d2 Benzbromarone 6-Hydroxy Impurity Benzbromarone Impurity 7 (6-Hydroxy-Benzbromarone) (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxybenzofuran-3-yl)methanone METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-
CAS	152831-00-0

Benzbromarone Impurity 7 (6-Hydroxy-Benzbromarone) - Physico-chemical Properties

Molecular Formula	C17H12Br2O4
Molar Mass	440.08
In vitro study	6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding. Cell Proliferation Assay Cell Line: HUVEC cells Concentration: 7.5 μM Incubation Time: 72 hours Result: Inhibited HUVEC cells proliferation.

Benzbromarone Impurity 7 (6-Hydroxy-Benzbromarone) - Introduction

(3, a) (methanone) is an organic compound, also known as 6-hydroxybenzotriazole or HOBt for short. The following is some information about the properties, uses, preparation and safety of (3,) methanone.

Nature:
(3,-) methanone is a white crystalline solid, soluble in organic solvents such as ethanol and dimethylformamide. It has a neutral pH and a high melting point.

Use:
(3,) methanone is often used as a coupling reagent and activator in organic synthesis, especially in the synthesis of macromolecular drugs and peptides or coupling reactions in natural products. It can effectively increase the reaction rate and yield, and improve the purity of the produced product.

Preparation Method:
(3,) (()) The preparation of methanone can be obtained by the reaction of benzbromarone and sodium hydroxide. First, benzbromarone is dissolved in an alcohol solvent, then sodium hydroxide solution is added for reaction, and finally the target product is obtained by crystallization.

Safety Information:
Under the correct use conditions,(3, and) methanone is relatively safe. However, it may cause irritation to the eyes, respiratory system and skin. Therefore, it is necessary to take appropriate protective measures during operation, such as wearing protective glasses, gloves and respiratory protection. At the same time, it should be kept in a dry, cool place, away from fire and oxidant.

It is worth noting that the use of chemicals needs to follow correct operating procedures and laboratory safety regulations to ensure the safety and health of laboratory personnel.

Last Update：2024-04-09 21:11:58