Benzeneacetic acid, 2-hydroxy-, methyl ester

Benzeneacetic acid, 2-hydroxy-, methyl ester - Names and Identifiers

Name	methyl (2-hydroxyphenyl)acetate
Synonyms	Methyl o-hydroxyphenylacetate METHYL 2-HYDROXYPHENYL ACETATE Methyl 2-hydroxybenzeneacetate methyl (2-hydroxyphenyl)acetate Methyl 2-(2-hydroxyphenyl)acetate methyl 2-(2-hydroxyphenyl)acetate 2-Hydroxybenzeneacetic acid methyl ester (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER (2-hydroxy-phenyl)-acetic acid methyl ester Benzeneacetic acid, 2-hydroxy-, methyl ester Acetic acid, (o-hydroxyphenyl)-, methyl ester
CAS	22446-37-3
EINECS	245-004-5
InChI	InChI=1/C9H10O3/c1-12-9(11)6-7-4-2-3-5-8(7)10/h2-5,10H,6H2,1H3

Benzeneacetic acid, 2-hydroxy-, methyl ester - Physico-chemical Properties

Molecular Formula	C9H10O3
Molar Mass	166.17
Density	1.181±0.06 g/cm3(Predicted)
Melting Point	122-124℃
Boling Point	115-120℃ (0.3 Torr)
Flash Point	110°C
Solubility	Chloroform, Methanol (Slightly)
Vapor Presure	0.00692mmHg at 25°C
Appearance	Solid
Color	Off-White to Light Brown
pKa	9.55±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.539
Physical and Chemical Properties	This product is white powder Crystal, m. P. 70~72 ℃, difficult to dissolve in water, soluble in benzene, toluene, acetone.

Benzeneacetic acid, 2-hydroxy-, methyl ester - Reference Information

use

methyl 2-hydroxyphenylacetate is an intermediate of the fungicide azoxystrobin.

production method

its preparation method is to add 2-hydroxyphenylacetic acid to methanol solution containing thionyl chloride, stir for 3 hours at room temperature, then filter, the residue obtained by concentration of the reaction liquid under reduced pressure, dissolve in ether, wash with sodium bicarbonate solution, wash with water, and recrystallize the residue obtained by distillation of the ether solution with ether/petroleum ether to obtain the product.

Last Update：2024-04-09 21:04:16