Benzyl hydrazine Di HCl
Benzylhydrazine dihydrochloride
CAS: 20570-96-1
Molecular Formula: C7H12Cl2N2
Benzyl hydrazine Di HCl - Names and Identifiers
Benzyl hydrazine Di HCl - Physico-chemical Properties
| Molecular Formula | C7H12Cl2N2 |
| Molar Mass | 195.09 |
| Density | 0.628g/cm3 at 23℃ |
| Melting Point | 143-145°C (dec.)(lit.) |
| Boling Point | 149.5℃ at 95.5kPa |
| Water Solubility | Insoluble in water. |
| Appearance | Yellow to light brown powder |
| Color | Slightly yellow to beige |
| BRN | 3688990 |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00012921 |
Benzyl hydrazine Di HCl - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | MU8540000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29280000 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
| Toxicity | LD50 ipr-mus: 11 mg/kg JMCMAR 18,20,75 |
Benzyl hydrazine Di HCl - Reference Information
| dissociation constant | 0.001-0.001 at 23 ℃ |
| application | benzylhydrazine dihydrochloride is an intermediate in organic synthesis and pharmaceutical research and development, which can be used in laboratory organic research and development processes and chemical and pharmaceutical synthesis processes. |
| preparation | step 1: experimental method for preparing tert-butyl isopropylidene hydrazinic acid ester (1): adding MgSO4 (about 2g) and 5 drops of HOAc to acetone (75mL) solution of tert-butyl formate (10g,75.6mmol). The mixture is heated to reflux for 1 hour, then cooled, filtered and vacuum concentrated. White solid, yield 12.58g(97%). Melting point 85-87 ℃. Step 2: General/Typical Procedure: General Preparation of Alkylated Hydrazone (2): Solid KOH (powder, 218mg,3.9mmol) and tetrabutylammonium bisulfate (100mg,0.3mmol) are added to a solution of tert-butyl isopropylidene decanoate (1) 10(516mg,3.0mmol) toluene (10mL) solution. Stir the mixture vigorously and heat to 50°C, then slowly add pure alkyl bromide (3.6mmol). Raise the temperature to 80°C and keep it until the reaction is complete, as shown in GC-MS analysis (1-3 hours). The mixture was cooled and washed with H2O until the aqueous extract had a neutral pH. The organic layer is dried (MgSO4) and vacuum concentrated to obtain a light-colored oil (2), which can be used without further purification. 2f(R = benzyl), yield 93%. Step 3: General/Typical Procedure: Monoalkyl Hydrazine (3): Add 2N HCl(2 acid equivalents) to 2 THF(0.5M) solution and heat it under reflux for 3 hours. Cool the mixture and vacuum concentrate. The residue was completely dried by adding and vacuum removing toluene (3 ×), and the yield was calculated. The resulting dihydrochloride 12 was diluted with EtOH, filtered through a filter disc (0.2mm) to remove fine particles, and stored in an amber vial at ambient temperature. 3f(R = benzyl), yield 99%. |
| use | is an intermediate in organic synthesis and pharmaceutical research and development, which can be used in laboratory organic research and development processes and chemical pharmaceutical synthesis processes. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-mouse LD50: 11 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxides and hydrogen chloride smoke |
| storage and transportation characteristics | ventilation and low temperature drying; separate from warehouse food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 21:04:16
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