Bis(4-anisyl) ketone
4,4'-Dimethoxybenzophenone
CAS: 90-96-0
Molecular Formula: C15H14O3
Bis(4-anisyl) ketone - Names and Identifiers
| Name | 4,4'-Dimethoxybenzophenone |
| Synonyms | Bis(4-anisyl) ketone LABOTEST-BB LT00160175 4,4-Dimethoxy Benzophenone 4,4'-Dimethoxybenzophenone P,P'-DIMETHOXYBENZOPHENONE 4,4'-DIMETHOXYBENZOPHENONE BIS(P-METHOXYPHENYL)-KETONE 4,4,4'-Dimethoxybenzophenone bis(4-methoxyphenyl)methanone Benzophenone, 4,4'-dimethoxy- |
| CAS | 90-96-0 |
| EINECS | 202-028-0 |
| InChI | InChI=1/C15H14O3/c1-17-13-7-3-11(4-8-13)15(16)12-5-9-14(18-2)10-6-12/h3-10H,1-2H3 |
| InChIKey | RFVHVYKVRGKLNK-UHFFFAOYSA-N |
Bis(4-anisyl) ketone - Physico-chemical Properties
| Molecular Formula | C15H14O3 |
| Molar Mass | 242.27 |
| Density | 1.1515 (rough estimate) |
| Melting Point | 141-143 °C (lit.) |
| Boling Point | 200°C17mm Hg(lit.) |
| Flash Point | 182°C |
| Water Solubility | It is insoluble in water, soluble in ethanol. |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Vapor Presure | 2.49E-06mmHg at 25°C |
| Appearance | White to yellow crystals |
| Color | Slightly beige to yellow |
| BRN | 1878026 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5570 (estimate) |
| MDL | MFCD00008404 |
Bis(4-anisyl) ketone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29145000 |
| Hazard Note | Irritant |
Bis(4-anisyl) ketone - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Application | 4,4 '-dimethoxybenzophenone is a symmetric diaryl ketone. Symmetrical diaryl ketones are important intermediates in organic synthesis, and have been widely used in the fields of medicine, pesticide and polymer materials. For example, benzophenone is a key intermediate for the preparation of the anti-vertigo drugs diphenhydramine and difenidol, and 4,4 '-difluorobenzophenone is a key intermediate for the preparation of the cerebrovascular drug florfenicol. In addition, many natural products and pharmaceutically active molecules contain the backbone structure of symmetric diaryl ketones. |
| preparation | p-methoxyphenylboronic acid (2mmol), 5wt%Pd/CaCO3(0.0456g, pd 0.01mmol) and CuI(0.0114g,0.03mmol) were added to a 250mL Teflon-lined pressure reaction kettle, DMSO(10ml) was added, 1.85ATM of air was slowly introduced into the fume hood, followed by 0.15atm of CO, and the reaction vessel was placed in an oil bath at 50 ° C. For 12 hours. After the reaction was stopped, the reaction vessel was cooled to room temperature, and the remaining gas in the vessel was slowly discharged in the fume hood. The reaction kettle is turned on, 40ml of ammonia water with mass concentration of 5% is added, and the Palladium catalyst is filtered and separated. The catalyst can be reused after washing and drying. The mother liquor was extracted with dichloromethane (30mL) for three times, the organic phase was combined, the organic phase was dried over anhydrous sodium sulfate, and the solvent was removed by vacuum concentration to obtain the crude product, which was purified by column chromatography (volume ratio: 20:1 petroleum ether/ethyl acetate as eluent) to give 4,4 '-dimethoxybenzophenone in 76% yield and the product as a white solid. |
Last Update：2024-04-09 21:01:54
Supplier List
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Request for quotationCAS: 90-96-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Request for quotationCAS: 90-96-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Request for quotationCAS: 90-96-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Request for quotationCAS: 90-96-0
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Visit Supplier Webpage Request for quotationCAS: 90-96-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 4,4'-Dimethoxybenzophenone Request for quotation
CAS: 90-96-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 90-96-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Request for quotationCAS: 90-96-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Request for quotationCAS: 90-96-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Request for quotationCAS: 90-96-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Request for quotationCAS: 90-96-0
Tel: 15335994747
Email: 3521670276@qq.com
Mobile: 15335994747
QQ: 3521670276
Wechat: A2020071098
Spot supply
Product Name: 4,4'-Dimethoxybenzophenone Visit Supplier Webpage Request for quotationCAS: 90-96-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 4,4'-Dimethoxybenzophenone Request for quotation
CAS: 90-96-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 90-96-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
View History