Bis-J Acid
4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid
CAS: 134-47-4
Molecular Formula: C21H16N2O9S2
Bis-J Acid - Names and Identifiers
| Name | 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid |
| Synonyms | Bis-J Acid J Acid Urea phosgenated 6,6'-ureylenbis-1-naphthol-3-sulfonic acid N,N'-Bis[6-(1-naphthol-3-sulfonic acid)]urea 6,6'-ureylene-bis(1-naphthol-3-sulfonic acid) 5,5-DIHYDROXY-7,7-DISULPHO-2,2-DINAPHTHYL UREA N,N'-bis(4-hydroxy-2-sulfonaphthalene-7-yl)urea 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid) 7,7'-Ureylene-bis-(4-hydroxynaphthalene-2-sulfonic acid) 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid) 7,7-(carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] 2-Naphthalenesulfonic acid, 7,7-(carbonyldiimino)bis4-hydroxy- 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] 4-hydroxy-7-{[(5-hydroxy-7-sulfonaphthalen-2-yl)carbamoyl]amino}naphthalene-2-sulfonic acid |
| CAS | 134-47-4 |
| EINECS | 205-142-9 |
| InChI | InChI=1/C21H16N2O9S2/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32) |
Bis-J Acid - Physico-chemical Properties
| Molecular Formula | C21H16N2O9S2 |
| Molar Mass | 504.49 |
| Density | 1.798±0.06 g/cm3(Predicted) |
| Melting Point | 86-88 ℃ |
| Appearance | Dry gray-white powder |
| pKa | -0.17±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.822 |
| Use | As an intermediate for azo dyes, used in the manufacture of direct Orange S, direct acid fast red 4BS, etc |
Bis-J Acid - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | AMI-1 free acid is an effective, cell-permeable, reversible protein arginine N-methyltransferase (PRMTs) inhibitor, The IC50 values for human PRMT1 and yeast Hmt1p are 8.8 μM and 3.0 μM respectively. AMI-1 free acid exerts an inhibitory effect on PRMTs by blocking peptide-substrate binding. |
| Target | Value |
| HMT () | |
| human PRMT1 () | |
| yeast Hmt1p (Cell-free assay) | 3.0 μM |
| Cell Line: | S180 cells, U2OS cells S180 cells |
| Concentration: | 0.6 mM, 1.2 mM, 2.4 mM 1.2 mM, 2.4 mM |
| Incubation Time: | 48 hours, 72 hours, 96 hours 48 hours, 72 hours |
| Result: | Inhibited the cell viability. Increased the percentages of cells undergoing apoptosis. Decreased tumor weight. |
| Animal Model: | 6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft |
| Dosage: | 0.5 mg |
| Administration: | Intratumorally, daily, for 7 days |
| use | is an intermediate for azo dyes, used to make direct orange s, direct acid-resistant red 4BS, etc. |
Last Update：2024-04-10 22:29:15
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