Bismuth (Ⅲ)Subsalicylate
Bismuth subsalicylate
CAS: 14882-18-9
Molecular Formula: C7H5BiO4
Bismuth (Ⅲ)Subsalicylate - Names and Identifiers
| Name | Bismuth subsalicylate |
| Synonyms | C07870 bismuth oxygen(-2) anion 2-hydroxybenzoate Bismuth subsalicylat Bismuth subsalicylate Bismuth hyposalicylate Bismuth(II) subsalicylate Bismuth (Ⅲ)Subsalicylate Bismuth subsalicylate usp34 Bismuth Subsalicylate (100 mg) bismuth(3+) tris(2-hydroxybenzoate) benzoate, 2-hydroxy-, bismuth(3+) salt Bismuth subsalicylate, USP XVI-PH.FrX° Edition benzoic acid, 2-hydroxy-, bismuth salt, monohydrate |
| CAS | 14882-18-9 |
| EINECS | 238-953-1 |
| InChI | InChI=1/C7H6O3.Bi.O/c8-6-4-2-1-3-5(6)7(9)10;;/h1-4,8H,(H,9,10);;/q;+3;-2/p-1 |
| InChIKey | ZREIPSZUJIFJNP-UHFFFAOYSA-K |
Bismuth (Ⅲ)Subsalicylate - Physico-chemical Properties
| Molecular Formula | C7H5BiO4 |
| Molar Mass | 362.09 |
| Density | 3.05[at 20℃] |
| Melting Point | >350°C(lit.) |
| Boling Point | 336.3°C at 760 mmHg |
| Flash Point | 144.5°C |
| Water Solubility | Practically insoluble in water, alcoholSoluble in acid and alkali. Insoluble in cold water, ethanol, diethyl ether and n-octanol. |
| Solubility | Soluble in acid and alkali, insoluble in water, alcohol and ether. |
| Vapor Presure | 0Pa at 20℃ |
| Appearance | White to off-white crystalline powder |
| Color | White |
| Merck | 14,1285 |
| BRN | 9170211 |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Sensitive to light |
| MDL | MFCD00085368 |
| Physical and Chemical Properties | White or off-white powder. Soluble in acid, alkali, insoluble in water, alcohol and ether. Odorless, tasteless, easy to deteriorate when exposed to light, and decomposed when exposed to boiling water. Preparation Method: from salicylic acid and bismuth hydroxide condensation obtained. The bismuth nitrate was stirred and emulsified with water, hydrolyzed to bismuth hydroxide with 30% aqueous ammonia, filtered, washed with water and then reacted with salicylic acid, and then the resulting bismuth subsalicylate was filtered out and washed with 50 ℃ water until neutral, drying, sieving, to obtain the finished product. Purposes: Anti-spirochete disease drugs. |
| In vitro study | Bismuth Subsalicylate reduces inflammation/irritation of the stomach and intestinal lining by inhibiting prostaglandin G/H synthase 1/2. Bismuth Subsalicylate is the active ingredient in Pepto-Bismol, Pepto-Bismol an anti-diarrheal and antacid. In the gastrointestinal tract, Bismuth Subsalicylate is converted to salicylic acid and insoluble Bismuth salts. |
Bismuth (Ⅲ)Subsalicylate - Risk and Safety
| WGK Germany | 3 |
| RTECS | EB2985000 |
| TSCA | No |
| HS Code | 2918215100 |
Bismuth (Ⅲ)Subsalicylate - Introduction
Odorless, tasteless, easy to deteriorate when exposed to light, and decompose in boiling water.
Last Update：2022-10-16 17:14:03
Bismuth (Ⅲ)Subsalicylate - Reference Information
| LogP | 0.11 at 25℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | bismuth salicylate can be used to treat stomach discomfort, indigestion, nausea, heartburn and diarrhea. |
| pharmacological action | bismuth salicylate covers the surface of gastric mucosa to protect gastric mucosa and reduce adverse gastric stimulation; Anti-secretory effect; Adsorption of bacteriocins (such as toxins produced by Escherichia coli or enterotoxins produced by Vibrio cholerae); Direct antibacterial activity against pathogenic microorganisms. |
| side effects | the use of bismuth salicylate can cause mild constipation, which will disappear after stopping the drug and will not affect the continuation of the drug. |
| biological activity | Bismuth Subsalicylate is an active ingredient of Pepto-Bismol and can inhibit prostaglandin G/H synthase 1/2. |
| Target | Value |
| use | anti-spirochetes. Used as an antibacterial drug |
| Production method | is obtained by condensation of salicylic acid and bismuth hydroxide. First add water to stir and emulsify bismuth nitrate, add 30% ammonia water to hydrolyze into bismuth hydroxide, filter, wash with water and react with salicylic acid condensation, filter out the generated bismuth subsalicylic acid, wash with 50 ℃ water to Neutral, dry and sift to obtain the finished product. Use: Anti-spirochetes. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:48
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