Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid

Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid - Names and Identifiers

Name	Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid
Synonyms	RARECHEM AK PT B013 BOC-D-ALA(2-THIENYL)-(C*CH2)OH BOC-D-BETA-HOALA(2-THIENYL)-OH BOC-(2-THIENYL)-D-BETA-HOMOALANINE Boc-(R)-3-Amino-4-(2-thienyl)-butyric BOC-(R)-3-AMINO-4-(2-THIENYL)BUTANOIC ACID Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid BOC-(R)-3-AMINO-4-(2-THIENYL)-BUTYRIC ACID (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(thiophen-2-yl)butanoic acid
CAS	269726-89-8

Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid - Physico-chemical Properties

Molecular Formula	C13H19NO4S
Molar Mass	285.36
Density	1.216
Boling Point	449.3±40.0 °C(Predicted)
pKa	4.38±0.10(Predicted)
Storage Condition	2-8°C(protect from light)

Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid - Risk and Safety

Hazard Class

IRRITANT

Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid - Introduction

Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid is an organic compound with the following properties:

1. appearance: usually white or white solid.
2. molecular formula: C13H17NO4S.
3. Molecular weight: 291.35g/mol.
4. melting point: about 90-92 degrees Celsius.
5. Solubility: It is easy to dissolve in organic solvents such as ethanol and acetone.

Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid is mainly used as follows:

1. as a chiral reagent and chiral building block in organic synthesis, used in the synthesis of chiral heterocyclic compounds, chiral drugs, etc.
2. Used as a protecting group (Boc protecting group) in the synthesis of amino acids and peptides.
3. for the synthesis of peptide drugs, antibiotics and other organic compounds.

In terms of preparation, Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid can be synthesized through the following steps:

1. First, 2-thiophenyl butyric acid was obtained by esterification of 2-thiophenol methanol and butyric acid catalyzed by sodium carbonate.
2. Esterification of 2-thienyl butyric acid with bromoacetic acid to generate ethyl 2-thienyl butyrate.
3. Finally, 2-thienylbutyric acid ethyl ester was condensed with aminobutyric acid and acidified with n-butanol to obtain Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid.

For safety information, Boc-(S)-3-Amino-4-(2-thienyl)-butyric acid has low toxicity and danger under general operating conditions. But in the use and storage still need to pay attention to the following matters:

1. Avoid direct contact with skin and eyes to avoid irritation or allergic reactions.
2. in the process of operation, should pay attention to good ventilation, and wear appropriate protective equipment, such as gloves, glasses, etc.
3. Avoid inhaling dust or vapor, and the workplace should be kept clean and tidy.
4. in storage, should keep dry, cool environment, away from fire and oxidant.

Last Update：2024-04-09 21:50:46