Boc-L-Histidine(Tosyl)
N(alpha)-boc-N(im)-tosyl-L-histidine
CAS: 35899-43-5
Molecular Formula: C18H23N3O6S
Boc-L-Histidine(Tosyl) - Names and Identifiers
| Name | N(alpha)-boc-N(im)-tosyl-L-histidine |
| Synonyms | BOC-HIS(TOS) BOC-L-HIS(TOS) Boc-His(Tos)-OH BOC-HIS(TOS)-OH Boc-L-His(Tos)-OH BOC-L-HIS(TOS)-OH BOC-HIS(TOS)-OH IPA BOC-HISTIDINE(TOS)-OH Boc-L-Histidine(Tosyl) BOC-L-HISTIDINE(TOSYL) N(alpha)-boc-N(im)-tosyl-L-histidine BOC-N-IM-4-TOLUENESYLFONYL-L-HISTIDINE N-T-boc-im-tosyl-L-histidine free acid Butoxycarbonyltoluenosulfonylhistidine N-(tert-butoxycarbonyl)-1-[(4-methylphenyl)sulfonyl]-L-histidine N-(tert-butoxycarbonyl)-1-[(4-methylphenyl)sulfonyl]-D-histidine |
| CAS | 35899-43-5 |
| InChI | InChI=1/C18H23N3O6S/c1-12-5-7-14(8-6-12)28(25,26)21-10-13(19-11-21)9-15(16(22)23)20-17(24)27-18(2,3)4/h5-8,10-11,15H,9H2,1-4H3,(H,20,24)(H,22,23)/t15-/m1/s1 |
Boc-L-Histidine(Tosyl) - Physico-chemical Properties
| Molecular Formula | C18H23N3O6S |
| Molar Mass | 409.46 |
| Density | 1.19 |
| Melting Point | ~125°C (dec.) |
| Appearance | Bright yellow crystal |
| Color | White to Almost white |
| BRN | 769957 |
| pKa | 3.50±0.10(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.594 |
| MDL | MFCD00065967 |
Boc-L-Histidine(Tosyl) - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29350090 |
Boc-L-Histidine(Tosyl) - Introduction
N(alpha)-boc-N(im)-tosyl-L-histidine(N(alpha)-boc-N(im)-tosyl-L-histidine) is a compound. Here are some information about its nature, use, formulation and safety:
Nature:
-Appearance: White crystalline solid
-Molecular formula: C25H30N4O6S
-Molecular weight: 514.60g/mol
-Melting point: 158-161 degrees Celsius
-Solubility: Soluble in alcohols, ketones and some organic solvents
Use:
- N(alpha)-boc-N(im)-tosyl-L-histidine can be used as a protecting group to protect the histidine functional group during peptide synthesis.
-In peptide chemistry, it can be used as a precursor compound for the synthesis of biologically active polypeptides.
Preparation Method:
The preparation of N(alpha)-boc-N(im)-tosyl-L-histidine is relatively complex and requires a series of chemical steps. A common preparation method is to react tert-butyl chloroformate with L-histidine imidazole ester, and then react with methylbenzenesulfonyl chloride to obtain the target product.
Safety Information:
- N(alpha)-boc-N(im)-tosyl-L-histidine may be irritating and sensitizing to humans.
-During handling and storage, it is recommended to take appropriate personal protective measures, such as wearing gloves, goggles and protective clothing.
-Avoid contact with skin, eyes and respiratory tract, and maintain a well-ventilated laboratory environment.
-When using and disposing of this compound, relevant safety procedures and regulations should be followed.
Nature:
-Appearance: White crystalline solid
-Molecular formula: C25H30N4O6S
-Molecular weight: 514.60g/mol
-Melting point: 158-161 degrees Celsius
-Solubility: Soluble in alcohols, ketones and some organic solvents
Use:
- N(alpha)-boc-N(im)-tosyl-L-histidine can be used as a protecting group to protect the histidine functional group during peptide synthesis.
-In peptide chemistry, it can be used as a precursor compound for the synthesis of biologically active polypeptides.
Preparation Method:
The preparation of N(alpha)-boc-N(im)-tosyl-L-histidine is relatively complex and requires a series of chemical steps. A common preparation method is to react tert-butyl chloroformate with L-histidine imidazole ester, and then react with methylbenzenesulfonyl chloride to obtain the target product.
Safety Information:
- N(alpha)-boc-N(im)-tosyl-L-histidine may be irritating and sensitizing to humans.
-During handling and storage, it is recommended to take appropriate personal protective measures, such as wearing gloves, goggles and protective clothing.
-Avoid contact with skin, eyes and respiratory tract, and maintain a well-ventilated laboratory environment.
-When using and disposing of this compound, relevant safety procedures and regulations should be followed.
Last Update：2024-04-10 22:29:15
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