Boronic acid, B-(2-ethoxy-4-fluorophenyl)-
2-Ethoxy-4-fluorophenylboronic acid
CAS: 480438-58-2
Molecular Formula: C8H10BFO3
Boronic acid, B-(2-ethoxy-4-fluorophenyl)- - Names and Identifiers
| Name | 2-Ethoxy-4-fluorophenylboronic acid |
| Synonyms | 2-Ethoxy-4-fL 2-Ethoxy-4-fluorophenylboronic acid 2-ETHOXY-4-FLUOROPHENYLBORONIC ACID (2-Ethoxy-4-fluorophenyl)boronic acid boronic acid, B-(2-ethoxy-4-fluorophenyl)- Boronic acid, B-(2-ethoxy-4-fluorophenyl)- 2-Ethoxy-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) |
| CAS | 480438-58-2 |
| InChI | InChI=1/C8H10BFO3/c1-2-13-8-5-6(10)3-4-7(8)9(11)12/h3-5,11-12H,2H2,1H3 |
Boronic acid, B-(2-ethoxy-4-fluorophenyl)- - Physico-chemical Properties
| Molecular Formula | C8H10BFO3 |
| Molar Mass | 183.97 |
| Density | 1.22±0.1 g/cm3(Predicted) |
| Melting Point | 136-141°C(lit.) |
| Boling Point | 307.0±52.0 °C(Predicted) |
| Flash Point | 139.484°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 8.71±0.58(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.501 |
Boronic acid, B-(2-ethoxy-4-fluorophenyl)- - Risk and Safety
| WGK Germany | 3 |
Boronic acid, B-(2-ethoxy-4-fluorophenyl)- - Introduction
The acid is an organic compound containing boron and fluorine groups. Its chemical formula is C8H10BFO3 and its molecular weight is 183.97g/mol.
The following are some of the properties and characteristics of acid:
-Appearance: White to light yellow crystal
-Solubility: Soluble in some organic solvents such as chloroform, dimethylformamide and ether
-Stability: stable at room temperature, but may decompose under the action of high temperature or strong oxidants
Ti acid can be used in the coupling reaction of aryl boronic acid in organic synthesis, and can be used as an important reagent and intermediate. It can react with other organic compounds to generate different types of compounds such as esters, alcohols, ethers, etc.
The method of preparing the Ti acid is as follows:
First, 4-fluorophenylboronic acid and ethoxyethyl chloride are reacted in the presence of alkali to generate acid ethyl ester. Then, hydrolyze the phenol acid ethyl ester to obtain phenol acid.
Regarding safety information, the specific toxicity and hazards of acid need to be studied in more detail, and there is no clear report. However, as a chemical substance, care should be taken to follow routine laboratory safety procedures and avoid inhalation, ingestion and contact with skin and eyes.
The following are some of the properties and characteristics of acid:
-Appearance: White to light yellow crystal
-Solubility: Soluble in some organic solvents such as chloroform, dimethylformamide and ether
-Stability: stable at room temperature, but may decompose under the action of high temperature or strong oxidants
Ti acid can be used in the coupling reaction of aryl boronic acid in organic synthesis, and can be used as an important reagent and intermediate. It can react with other organic compounds to generate different types of compounds such as esters, alcohols, ethers, etc.
The method of preparing the Ti acid is as follows:
First, 4-fluorophenylboronic acid and ethoxyethyl chloride are reacted in the presence of alkali to generate acid ethyl ester. Then, hydrolyze the phenol acid ethyl ester to obtain phenol acid.
Regarding safety information, the specific toxicity and hazards of acid need to be studied in more detail, and there is no clear report. However, as a chemical substance, care should be taken to follow routine laboratory safety procedures and avoid inhalation, ingestion and contact with skin and eyes.
Last Update：2024-04-10 22:29:15
