Boronic acid, B-(3,5-difluoro-4-formylphenyl)-

Boronic acid, B-(3,5-difluoro-4-formylphenyl)- - Names and Identifiers

Name	(3,5-difluoro-4-formylphenyl)boronic acid
Synonyms	(3,5-difluoro-4-formylphenyl)boronic acid Boronic acid, B-(3,5-difluoro-4-formylphenyl)- 3,5-Difluoro-4-formylphenylboronic acid(contains varying amounts of Anhydride)
CAS	870718-11-9
InChI	InChI=1/C7H5BF2O3/c9-6-1-4(8(12)13)2-7(10)5(6)3-11/h1-3,12-13H

Boronic acid, B-(3,5-difluoro-4-formylphenyl)- - Physico-chemical Properties

Molecular Formula	C7H5BF2O3
Molar Mass	185.92
Density	1.42±0.1 g/cm3(Predicted)
Melting Point	255-260°C
Boling Point	342.1±52.0 °C(Predicted)
Flash Point	160.7°C
Vapor Presure	2.95E-05mmHg at 25°C
pKa	5.21±0.11(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.503
MDL	MFCD07784344

Boronic acid, B-(3,5-difluoro-4-formylphenyl)- - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
Hazard Class	IRRITANT

Boronic acid, B-(3,5-difluoro-4-formylphenyl)- - Reference

Reference

1. Yin, Jialuo, et al. "Boronic acid‐functionalized agarose affinity chromatography for isolation of tropomyosin in fishes." Journal of the Science of Food and Agriculture 99.14 (2019): 6490-6499.https://doi.org/10.1002/jsfa.9928
2. [IF=3.638] Jialuo Yin et al."Boronic acid-functionalized agarose affinity chromatography for isolation of tropomyosin in fishes."J Sci Food Agr. 2019 Nov;99(14):6490-6499

Boronic acid, B-(3,5-difluoro-4-formylphenyl)- - Introduction

(3,5-difluoro-4-formylphenyl)boronic acid is an organic compound whose chemical formula is C7H5BF2O3. It has a melting point of 140°C to 144°C and a molecular weight of 183.92g/mol.

(3,5-difluoro-4-formylphenyl)boronic acid has a variety of applications. First, it is an important reagent commonly used in organic synthesis. It can be used to synthesize various organic compounds, such as ketones, olefins, alcohols and acids. Secondly, it can be used as a ligand to form complexes with transition metals, which can be used in catalytic chemistry and organic synthesis reactions. In addition,(3,5-difluoro-4-formylphenyl)boronic acid can also be used in the fields of pharmaceutical research and materials science.

The acid boronic the preparation of (3,5-difluororo-4-formylphenyl) can be obtained by the reaction of benzoyl chloride and 2,4-difluorophenylboronic acid. The specific operating conditions are that benzoyl chloride and 2,4-difluorophenylboronic acid are reacted in the presence of sodium carbonate to generate the target product, which is then dissolved in ether and filtered, and finally cooled to precipitate to obtain a pure product.

Regarding safety information,(3,5-difluoro-4-formylphenyl)boronic acid is an organic compound and must comply with laboratory safety practices. Care should be taken to avoid contact with skin, eyes and mucous membranes, and appropriate protective gloves, goggles and laboratory ventilation should be used. In the case of accidental contact, rinse immediately with plenty of water and seek medical assistance.

Last Update：2024-04-09 21:01:54