Bromo fluorobenzene
4-Bromofluorobenzene
CAS: 460-00-4
Molecular Formula: C6H4BrF
Bromo fluorobenzene - Names and Identifiers
Bromo fluorobenzene - Physico-chemical Properties
| Molecular Formula | C6H4BrF |
| Molar Mass | 175 |
| Density | 1.593g/mLat 25°C(lit.) |
| Melting Point | −16°C(lit.) |
| Boling Point | 150°C(lit.) |
| Flash Point | 140°F |
| Water Solubility | Soluble in water(0.14g/L). |
| Solubility | 0.136g/l |
| Vapor Presure | 4.99hPa at 25℃ |
| Appearance | Liquid |
| Color | Clear colorless |
| BRN | 774102 |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.527(lit.) |
| MDL | MFCD00000342 |
| Physical and Chemical Properties | Density 1.593 melting point -16°C boiling point 151-153°C refractive index 1.526-1.528 flash point 53°C |
| Use | For the synthesis of pharmaceuticals and pesticides |
Bromo fluorobenzene - Risk and Safety
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R20 - Harmful by inhalation R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S16 - Keep away from sources of ignition. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S7 - Keep container tightly closed. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 1 |
| RTECS | CY9033750 |
| TSCA | Yes |
| HS Code | 29036990 |
| Hazard Note | Flammable/Irritant |
| Hazard Class | 3 |
| Packing Group | III |
Bromo fluorobenzene - Introduction
Insoluble in water, soluble in methanol, ethanol, ether, acetone and 2-propanol.
Last Update：2022-10-16 17:25:18
Bromo fluorobenzene - Reference Information
| LogP | 3.018 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | 1-bromo-4-fluorobenzene is an intermediate of the fungicide flusilazole. Organic synthesis intermediates. Used in the synthesis of medicines and pesticides |
| production method | dry bromine drops are added to the boiling mixture of fluorobenzene and pyridine, and the hydrogen bromide produced by the reaction is absorbed with water. Then continue heating for 2h. Cooling, adding sodium hydroxide solution, extracting with ether, drying the extract with anhydrous potassium carbonate, and fractionation. The fraction at 75-90°C is unreacted fluorobenzene, and the fraction at 148-154°C is p-bromofluorobenzene. The yield is about 49%. The preparation method is to add fluorobenzene and a little iron powder as a catalyst in the reactor, add bromine at 5-15°C, and react at 40°C until bromine disappears to obtain a product. |
Last Update：2024-04-09 21:54:55
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