C.I. No. 45170
Rhodamine B
CAS: 81-88-9
Molecular Formula: C28H31ClN2O3
C.I. No. 45170 - Names and Identifiers
| Name | Rhodamine B |
| Synonyms | C.I. 45170 Rhodamine B Basic rose red Basic Viloet10 C.I. No. 45170 C.I. Food Red 15 Basic Violet 10 Basic Rhodamine B Tetraethylrhodamine C.I.Basic Violet 10 Rhodamine B solution C.I. Basic Violet 10 Basic Violet 10 (C.I.) rhodamine B (laser dye) Basic violet 10(C.I.45170) rhodamine B for microscopy 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride |
| CAS | 81-88-9 |
| EINECS | 201-383-9 |
| InChI | InChI=1/C28H30N2O3.ClH/c1-5-29(6-2)19-13-15-23-25(17-19)33-26-18-20(30(7-3)8-4)14-16-24(26)27(23)21-11-9-10-12-22(21)28(31)32;/h9-18H,5-8H2,1-4H3;1H |
C.I. No. 45170 - Physico-chemical Properties
| Molecular Formula | C28H31ClN2O3 |
| Molar Mass | 479.01 |
| Density | 0.79 g/mL at 20 °C |
| Melting Point | 210-211℃ (dec.) |
| Flash Point | 12 °C |
| Water Solubility | SOLUBLE |
| Solubility | Soluble in water and ethanol is blue red (with strong fluorescence), slightly soluble in acetone, easily soluble in glycol ether. |
| Appearance | Form Solid, Color Index 45170, Color Green |
| PH | 3-4 (10g/l, H2O, 20℃) |
| Storage Condition | room temp |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.6500 (estimate) |
| MDL | MFCD00011931 |
| Physical and Chemical Properties | Melting Point 210-211°C (dec.) water-SOLUBLE SOLUBLE |
| Use | Used as adsorption indicator and biological stain |
C.I. No. 45170 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R68 - Possible risk of irreversible effects |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | BP3675000 |
| TSCA | Yes |
| HS Code | 32041300 |
| Toxicity | LD50 i.v. in rats: 89.5 mg/kg (Webb) |
C.I. No. 45170 - Upstream Downstream Industry
C.I. No. 45170 - Reference
| Reference Show more | 1. Wang Ao-lin, Tan Zhao-yan, the King of equality. Preparation of 20% ENE · pentane · oxadiene coating agent and its control effect on Fusarium root rot of soybean [J]. Plant protection 2019 45(03):230-236. 2. Tan Zhao-yan, Kang Ze, Huang Hao-nan, et al. Preparation of suspension Seed Coating Agent with 8% ENE · propyl · A and its control effect on Fusarium root rot of soybean [J]. Journal of Nuclear Agricultural Sciences, 2020v.34(05):56-64. 3. Li Bin, Zhu Liang, Chen Lin, Liu Chang. Preparation and properties of g-C_3N_4 based PVDF distillation membrane [J]. Sichuan environment 2020 39(02):35-41. 4. Jin Liu, Zheng Yan, Peng Sun, et al. Development of laser-induced fluorescence detector with dual-wavelength linear spot [J]. Modern scientific instruments 2013(02):33-35. 5. Deng Ge, Yan Zheng, Huo Yongqiang, etc. Development and performance test of a simple practical laser induced fluorescence detector [J]. Stoichiometry for chemical analysis, 2012(3). 6. Sun Peng, Yan Zheng, Liu Jin, Xing Chao, Wang Liwei, Huo Yongqiang, Li Zhihui. Development and performance test of micro-cell detector for laser-induced fluorescence [J]. Journal of chemical analysis and metering, 2013,22(01):75-77. 7. Hao Yanhua, Yan Zheng, Deng Ge. Determination of Rhodamine B in onion powder by HPLC [J]. Chemical analysis and metrology, 2011, 20(6):77-79. 8. Yang Renhui, Hu Lili, Xu ganli, etc. Determination of Rhodamine B in capsicum products by high performance liquid chromatography with fluorescence detection [J]. Modern medicine and health care, 2013, 29(4):481-482. 9. Meng Jiangling, He DE, Li cuixin. Tolerance and enrichment characteristics of Cordyceps militaris to zinc [J]. Northern horticulture, 2021(06):123-128. 10. Li, Wei, et al. "Multilayer and multicast membrane filtration for separation and precondition of trace analytes and its application in spectral analysis." Analytical Methods 8.1 (2016): 129-135.DOI: 10.1039/C5AY02689J 11. Li, Wei, et al. "Development of on-line spectroscopic determination approach of dispersive liquid-liquid microextraction based on an effective device." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 124 (2014): 159-164.https://doi.org/ 12. Li, Wei, et al. "Determination of trace analytes based on diffuse reflectance spectroscopic techniques: development of a multichannel membrane filtration-enrichment device to improve repeatability ." RSC Advances 4.94 (2014): 52123-52129.DOI https://doi.org 13. Yan, Xiao-Xiao, et al. "Analysis of Process Parameters and Performance Test for Fabricating Stainless-steel Metal Microneedles." Sensors and Materials 30.6 (2018): 1333-1340. 14. [IF=4.207] Kongtong Yu et al."Role of Four Different Kinds of Polyethylenimines (PEIs) in Preparation of Polymeric Lipid Nanoparticles and Their Anticancer Activity Study."J Cancer. 2016; 7(7): 872-882 15. [IF=13.273] Yiru Gao et al."Microwave-triggered ionic liquid-based hydrogel dressing with excellent hyperthermia and transdermal drug delivery performance."Chem Eng J. 2022 Feb;429:131590 16. [IF=13.273] Shengyu Bai et al."Chemical reaction powered transient polymer hydrogels for controlled formation and free release of pharmaceutical crystals."Chem Eng J. 2021 Jun;414:128877 17. [IF=7.514] Gang You et al."Elucidation of interactions between gelatin aggregates and hsian-tsao gum in aqueous solutions."Food Chem. 2020 Jul;319:126532 18. [IF=7.182] Chengxiao Wang et al."Dissolvable microneedles based on Panax notoginseng polysaccharide for transdermal drug delivery and skin dendritic cell activation."Carbohyd Polym. 2021 May;:118211 19. [IF=5.909] Shaoru Liu et al."Highly efficient and stable Ag-g-C3N4/AC photocatalyst for photocatalytic degradation, Cr(VI) reduction and bacteriostasis under visible light irradiation."J Environ Chem Eng. 2021 Oct;9:105879 20. [IF=3.591] Guichen Li et al."Poly(HPMA)-chlorambucil conjugate nanoparticles: facile fabrication and in vitro anti-cancer activity."New J Chem. 2021 Oct;45(39):18544-18551 21. [IF=10.435] Sun Weidong et al."Self-oxygenation mesoporous MnO2 nanoparticles with ultra-high drug loading capacity for targeted arteriosclerosis therapy."J Nanobiotechnol. 2022 Dec;20(1):1-17 22. [IF=3.196] Peng Cao et al."Complecting the BiOCl nano-roundels based hollow microbasket induced by chitosan for dramatically enhancing photocatalytic activity."J Mol Struct. 2022 Apr;1254:132339 23. [IF=4.375] Zha Quanbin et al."Preparation and Study of Folate Modified Albumin Targeting Microspheres."J Oncol. 2022;2022:3968403 24. [IF=4.952] Yue Dong et al."Oleogel-based Pickering emulsions stabilized by ovotransferrin-carboxymethyl chitosan nanoparticles for delivery of curcumin."Lwt Food Sci Technol. 2022 Mar;157:113121 25. [IF=8.947] Yubo Liu et al."An injectable superior depot of Telratolimod inhibits post-surgical tumor recurrence and distant metastases."Acta Biomater. 2022 Jan;: 26. [IF=7.328] Ze Qiang Zhao et al."A high-dosage microneedle for programmable lidocaine delivery and enhanced local long-lasting analgesia."Mat Sci Eng C- Mater. 2021 Dec;:112620 27. [IF=4.282] Chunlan Jing et al."Bone-targeted polymeric nanoparticles as alendronate carriers for potential osteoporosis treatment."POLYMER TESTING. 2022 Jun;110:107584 |
C.I. No. 45170 - Uses and synthesis methods
introduction
Rhodamine B is a synthetic red alkaline fluorescent dye, commonly known as flower pink. The dye is often used as a fluorescent reagent and has been widely used in non-ferrous glass, mining, steel and other fields. It is a common basic dye in industry. Because Rhodamine B is easier to dye on hot pot condiments, chili products, etc. than other edible water-soluble dyes, and is not easy to fade, and the cost is low, so some illegal vendors use Rhodamine dyes to dye these foods with shoddy quality.
application
rhodamine B is mainly used for industrial dyeing and has fat solubility. rhodamine B has strong fluorescence in solution and is used as cell fluorescent dye, colored glass, characteristic fireworks and other industries in laboratory. It has also been used as a condiment (mainly chili powder and chili oil) stain. It was once used as a food additive, but later experiments proved that Rhodamine B can cause cancer and is now not allowed to be used as food stain.
properties
Rhodamine B is soluble in water and alcohol (a blue red solution with strong fluorescence), easily soluble in fibrinolytic, slightly soluble in acetone. When encountering concentrated sulfuric acid, it is yellow and brown with strong green fluorescence. After dilution, it turns into blue red and orange. Its aqueous solution and sodium hydroxide solution are heated to form a rose red fluffy precipitate.
use
Rhodamine B is mainly used for coloring paper and cosmetics, as well as for making lakes and dyeing silk. Used in paper industry to dye wax paper, typewriting paper, glossy paper, etc. It reacts with phosphorus tungsten molybdenum acid to form a lake.
harmfulness
Rhodamine B is extremely harmful to the human body, and can cause symptoms such as red staining of human skin and internal organs, mild congestion of blood vessels in the brain, rupture of myocardial fibers, blurred and disappearance of striations; human ingestion of rhodamine B, There is pulmonary edema, that is, a large number of homogeneous red stains are seen in the alveolar cavity, renal interstitial blood vessel congestion, and tubular cavity. Long-term ingestion will lead. According to the World Health Organization's International Agency for Research on Cancer (IARC) chemical carcinogenic risk assessment: rhodamine dye ingestion and skin exposure to the substance can cause acute and chronic poisoning.
chemical properties
bright green crystalline powder. Soluble in water and ethanol is blue red (with strong fluorescence), slightly soluble in acetone, easily soluble in glycol ether. It is yellow and brown in concentrated sulfuric acid, with strong green fluorescence, scarlet after dilution, and then blue red to orange. The aqueous solution is rose red when sodium hydroxide is added, and flocculent precipitate is produced after heating.
use
1. Rhodamine B is used for dyeing silk, acrylic fiber and wool. The sun fastness can reach grade 2-3. It is used for tannin mordant dyeing of cotton fiber. The sun fastness is poor. It is also used for coloring leather, paper, wheat straw and preparing lake pigments.
2, mainly used for dyeing wax paper, typewriting paper, glossed paper, etc. in papermaking industry. The lake is formed by the action of phosphorus tungsten molybdenum acid, which is used to make paints, pictures and other pigments. It can also be used for dyeing fabrics such as acrylic fiber, hemp, silk, wheat straw and leather products.
3. This product is used for dyeing paper, acrylic, silk, leather, feather, and can be used for food and certain metal analysis reagents
4, used as adsorption indicator and biological stain, etc.
5, for paper, paint, acrylic, wood dyeing
6. Biochemical studies
7, photometric determination of gold, gallium, mercury, antimony (V), thallium (III), fluorescence determination of manganese, cobalt, etc., colorimetric determination of cadmium. Redox indicator is used to titrate precipitants of tin, antimony, niobium, and tantalum. Biological stain. Series laser dyes.
production method
1. it is composed of m-hydroxydiethylaniline and phthalic anhydride, and then sodium hydroxide is used for alkali fusion, and then dissolved by sulfuric acid, crystallized by hydrochloric acid, salted out, filtered and dried to obtain the product. Raw material consumption (kg/t) m-hydroxydiethylaniline 760 phthalic anhydride 600 sulfuric acid 590 hydrochloric acid (31%) 390 sodium hydroxide (100%) 390 refined salt 120 Taikoo oil 19
2. using m-hydroxydiethylaniline (m-diethylaminophenol) and phthalic anhydride as raw materials, the finished product is obtained by condensation, alkali fusion, acid dissolution, crystallization and drying.
Last Update：2024-04-10 22:29:15
C.I. No. 45170 - Security information
| toxic substance data | 81-88-9(Hazardous Substances Data) |
Last Update：2024-04-10 22:29:15
C.I. No. 45170 - Nature
| solubility | H2O: soluble1mg/mL |
| Merck | 14,8183 |
| BRN | 4119648 |
| (IARC) Carcinogen Classification | 3 (Vol. 16, Sup 7) 1987 |
| NIST chemical information | Rhodamine B (81-88-9) |
| EPA chemical information | Rhodamine B (81-88-9) |
Last Update：2024-04-09 21:04:16
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View History
Raw Materials for C.I. No. 45170
Downstream Products for C.I. No. 45170
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Spirit Light Fast Fire Red B
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