CD38 inhibitor 78c
CD38 inhibitor 78c
CAS: 1700637-55-3
Molecular Formula: C22H27N3O3S
CD38 inhibitor 78c - Names and Identifiers
CD38 inhibitor 78c - Physico-chemical Properties
| Molecular Formula | C22H27N3O3S |
| Molar Mass | 413.536 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | MDK-7553, also known as CD38 inhibitor 78c and Compound-78c, is a potent CD38 inhibitor. MDK-7553 has CAS#1700637-55-3, which was reported in J Med Chem. 2015 Apr 23;58(8):3548-71. For the convenience of scientific communication, we name it as MDK-7553. The last four digits of CAS# were used for its name. |
| Target | IC50: 7.3 nM (hCD38), 1.9 nM (mouse CD38) Ki: 0.3 nM (WT hCD38) |
CD38 inhibitor 78c - Reference
| Reference Show more | 1: Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, JeuneMR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG,Shearer TW, Shewchuk LM, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC.Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitorsof NAD-Hydrolyzing Enzyme CD38. J Med Chem. 2015 Sep 10;58(17):7021-56. doi:10.1021/acs.jmedchem.5b00992. Epub 2015 Aug 24. PubMed PMID: 26267483. 2: Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, RudM, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL,Passos JF, Doles JD, Becherer DJ, Chini EN. A Potent and Specific CD38 InhibitorAmeliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline.Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.PubMed PMID: 29719225; PubMed Central PMCID: PMC5935140. |
CD38 inhibitor 78c - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.418 ml | 12.091 ml | 24.182 ml |
| 5 mM | 0.484 ml | 2.418 ml | 4.836 ml |
| 10 mM | 0.242 ml | 1.209 ml | 2.418 ml |
| 5 mM | 0.048 ml | 0.242 ml | 0.484 ml |
Last Update：2024-01-02 23:10:35
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