CDC25 Phosphatase Inhibitor I, BN82002

Name	BN82002 HYDROCHLORIDE SALT
Synonyms	BN-82002 BN 82002 BN82002 hydrochloride BN82002 HYDROCHLORIDE SALT CDC25 Phosphatase Inhibitor I CDC25 Phosphatase Inhibitor I, BN82002 Phenol, 4-(dimethylamino)-2-methoxy-6-[[methyl[2-(4-nitrophenyl)ethyl]amino]methyl]-
CAS	396073-89-5

Molecular Formula	C19H25N3O4
Molar Mass	359.42
Density	1.216±0.06 g/cm3(Predicted)
Melting Point	92-93 °C
Boling Point	532.6±50.0 °C(Predicted)
Solubility	DMSO: 10 mg/mL
Appearance	solid
Color	tan
pKa	10.07±0.48(Predicted)
Storage Condition	2-8°C
In vitro study	The effect of BN82002 on cell proliferation is evaluated in vitro on several human tumor cell lines. Menadione, which has been reported to inhibit cell proliferation, is used as a control. All of the examined cell lines are sensitive to BN82002 and Menadione in a concentration-dependent manner in the low micromolar range. The most sensitive is the pancreatic cancer cell line MIA PaCa-2 with an IC 50 of 7.2 μM, and the less sensitive cell line is the colon cancer HT-29 with an IC 50 of 32.6 μM. The range of activity is very similar to the one observed with menadione (5-15 μM). It is also showed that 50 μM BN82002 is a concentration that fully inhibits cell proliferation, the cell cycle distribution is only modestly affected with a slight decrease in S phase and an increase in cells containing both a G1 and a G2 DNA content, suggesting that the cells treated with BN82002 are arrested at various stages of the cell cycle.

WGK Germany

Last Update：2024-01-02 23:10:35

biological activity	BN82002 is a potent, selective, and irreversible pan-inhibitor of the CDC25 phosphatase family. BN82002 inhibited CDC25A,CDC25B2,CDC25B3,CDC25C CDC25A and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4 and 4.6 μm, respectively. BN82002 showed approximately 20-fold higher selectivity than CD45 tyrosine phosphatase.
Target	IC50: 2.4 μm (CDC25A), 3.9 μm (CDC25B2), 6.3 μm (CDC25B3), 5.4 μm (CDC25C), 4.6 μm (CDC25C-cat).

Last Update：2024-04-09 19:05:17

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Product Name: BN82002 HYDROCHLORIDE SALT Visit Supplier Webpage Request for quotation
CAS: 396073-89-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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CDC25 Phosphatase Inhibitor I, BN82002

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