CPI360

Name	CPI-360
Synonyms	CPI360 CPI 360 CPI-360 CPI-360 (R) 1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-
CAS	1802175-06-9

Molecular Formula	C25H31N3O4
Molar Mass	437.53
Density	1.26±0.1 g/cm3(Predicted)
Boling Point	712.2±60.0 °C(Predicted)
Solubility	DMSO: ≥ 48.9 mg/mL
pKa	11.01±0.10(Predicted)
Storage Condition	-20℃
In vitro study	In KARPAS-422 cells, CPI-360 effectively reduced overall H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM, respectively. CPI-360 also caused alterations in time-dependent transcription and affected the activity of the Y641N mutant in KARPAS-422 cells containing EZH2. In addition, CPI-360 gradually blocks KARPAS-422 cells at the G1 cell cycle stage and subsequently induces apoptosis.
In vivo study	In mice bearing KARPAS-422 xenografts, CPI-360 (200 mg/kg, s.c.) reduced tumor growth by 44%.

Last Update：2024-01-02 23:10:35

biological activity	CPI-360 is a potent, selective, and SAM competitive EZH1 inhibitor with an IC50 of 102.3 nM, the selectivity is more than 100-fold higher than for other methyltransferases.
Target	Value
EZH1 ()	102.3 nM

Last Update：2024-04-09 21:21:28

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Product Name: CPI-360 Visit Supplier Webpage Request for quotation
CAS: 1802175-06-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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CPI360

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