CYCLOBUTYL BROMIDE
bromocyclobutane
CAS: 4399-47-7
Molecular Formula: C4H7Br
CYCLOBUTYL BROMIDE - Names and Identifiers
| Name | bromocyclobutane |
| Synonyms | BROMOCYCLOBUTANE bromocyclobutane Cyclobutane,bromo- Cyclobutyl bromide CYCLOBUTYL BROMIDE Cyclobutane, bromo- |
| CAS | 4399-47-7 |
| EINECS | 224-530-9 |
| InChI | InChI=1/C4H7Br/c5-4-2-1-3-4/h4H,1-3H2 |
| InChIKey | KXVUSQIDCZRUKF-UHFFFAOYSA-N |
CYCLOBUTYL BROMIDE - Physico-chemical Properties
| Molecular Formula | C4H7Br |
| Molar Mass | 135 |
| Density | 1.434g/mLat 25°C(lit.) |
| Boling Point | 108°C(lit.) |
| Flash Point | 72°F |
| Water Solubility | Insoluble |
| Vapor Presure | 32mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless |
| BRN | 1900415 |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Sensitive | Light Sensitive |
| Refractive Index | n20/D 1.479(lit.) |
| Physical and Chemical Properties | Cyclobutyl bromide is colorless liquid at room temperature and pressure. Because the four-membered ring of cyclobutane bromide has a large ring tension, the stability of the compound is poor, and it is generally required to be stored at low temperature (2 to 8 degrees). |
CYCLOBUTYL BROMIDE - Risk and Safety
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S16 - Keep away from sources of ignition. |
| UN IDs | UN 1993 3/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8 |
| HS Code | 29038900 |
| Hazard Class | 3 |
| Packing Group | II |
CYCLOBUTYL BROMIDE - Reference Information
| chemical properties | cyclobutyl bromide is colorless liquid at normal temperature and pressure. because the four-membered ring of cyclobutane bromide has a large ring tension, the stability of the compound is poor, and it is generally required to be stored at low temperature (2 to 8 degrees). |
| Application | Cyclobutyl bromide can be used for drug molecules and organic synthesis intermediates. In organic synthesis and transformation, the most common application method is through cyclobutyl Bromide introduces the cyclobutyl group into the target molecule that needs to be modified, or converts the bromine atom in the structure into the corresponding sulfonyl chloride unit; in addition, cyclobutyl bromide can generate corresponding cyclobutene products by dehydrohalogenation. |
| synthesis method | the synthesis method of cyclobutyl bromide is as follows: add iodobenzene acetate and potassium bromide to the vacuum-dried reaction bottle, then slowly add dichloromethane and slowly add cyclobutyl formic acid under stirring. The air in the reaction system is replaced with corresponding oxygen by oxygen balls, and the obtained reaction system is stirred at room temperature, and the remaining amount of raw materials is monitored by TLC point plates. After the reaction of the raw materials is over, the insoluble precipitate in the reaction system is removed by filtration, the solid is washed with dichloromethane, all the organic layers are combined, and the organic layer is carefully concentrated (the boiling point of the product is also relatively low) The target product can be obtained. Figure The synthesis route of cyclobutyl bromide |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
Last Update：2024-04-09 20:52:54
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