Molecular Formula | C27H46O3 |
Molar Mass | 418.66 |
Boling Point | 529.2°C at 760 mmHg |
Flash Point | 14℃ |
Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
Vapor Presure | 2.07E-13mmHg at 25°C |
Appearance | White needle crystal |
Color | White to Light yellow |
BRN | 4270041 |
Storage Condition | -20°C |
MDL | MFCD00867077 |
Physical and Chemical Properties | White needle-like crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from which bacteria is derived from bacteria, vitamin D3 biotransformation (specific: vitamin D3 is added to actinomycetes for culture. Vitamin D3 is converted into ossifying diol by the action of microbial intracellular enzymes). |
In vitro study | Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival. |
Hazard Symbols | T+ - Very toxic |
Risk Codes | R28 - Very Toxic if swallowed R48/25 - R26 - Very Toxic by inhalation R24/25 - |
Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8-10-19 |
HS Code | 29362900 |
Application | ossifying diol has a role in the treatment of osteoporosis, the main circulating metabolite of vitamin D3, which is a competitive inhibitor, the Ki value was 3.9 μm. Calcium diol, the major circulating metabolite of vitamin D3, is a competitive inhibitor with an apparent Ki of 3.9 μm. Calcium diol is produced in the liver and is the best indicator of vitamin D storage in humans. Is effective in the treatment of rickets. |
biological activity | Calcifediol monohydrate (25-hydroxyvitamin D3 monohydrate) it is a prohormone obtained by hydroxylation of vitamin D3 in the liver and is a potent VDR inhibitor. |
Use | ossifying diol has a therapeutic effect on osteoporosis. The major circulating metabolite of vitamin D3, a competitive inhibitor with a Ki of 3.9 μm. |