Molecular Formula | C7H9AsN2O4 |
Molar Mass | 260.08 |
Melting Point | 174° |
Appearance | morphological solid |
pKa | 3.78±0.10(Predicted) |
Storage Condition | 2-8℃ |
Physical and Chemical Properties | Chemical properties white powder. Melting point 174 ℃. Slightly soluble in water and ethanol, soluble in sodium carbonate (potassium) solution or sodium hydroxide (potassium) solution, insoluble in ether and chloroform. Almost odorless, slightly sour in taste. |
Use | Uses Cabarsine is an anti-amoebic drug, mainly used for amoebic dysentery, and also used for the treatment of vaginal trichomoniasis. The oral LD50 of rats is 510mg/kg. |
Raw Materials | Water 4-Nitroaniline 4-Aminophenylarsonic acid Sodium cyanate NITARSONE ARSINE Cyanogen bromide Potassium cyanate |
Reference Show more | 1. [IF=4.792] Ke Huang et al."N-Hydroxyarylamine O-Acetyltransferases Catalyze Acetylation of 3-Amino-4-Hydroxyphenylarsonic Acid in the 4-Hydroxy-3-Nitrobenzenearsonic Acid Transformation Pathway of Enterobacter sp. Strain CZ-1 | Applied and Environmental Microbiology |
Production method
It is obtained by diazotization, arsine, reduction and addition of p-nitroaniline. 1. Diazotization Add p-nitroaniline to hydrochloric acid, stir and cool to -5 ℃, add sodium nitrite solution and react for 1h to obtain diazonium salt solution. 2. Arsine Add arsenic trioxide and sodium carbonate to water, stir and heat to 100°C to dissolve all, cool, add copper sulfate solution below 25°C, and then add the diazonium salt solution prepared in the previous step To the prepared sodium arsenite solution containing copper sulfate, the reaction temperature is controlled below 25°C to obtain p-nitrophenylarsonic acid solution. 3. The pH value of p-nitrophenylarsonic acid solution is adjusted to 2.8-3.2 with sulfuric acid for reduction, iron powder and sodium chloride are added, and the temperature is raised to 100 ℃ for reaction. The end point of the reaction is that the pH reaches above 9. Then add liquid alkali and leave for more than 3 hours. Filter, adjust the filtrate to 4.5 with sulfuric acid, add activated carbon, decolorize at 50-90 ℃. Filter, adjust the pH of the filtrate to 2.8-3.2 with sulfuric acid, cool to 10 ℃, filter and wash to obtain p-aminophenylarsonic acid. 4. Addition Add water to cool p-aminophenylarsonic acid to 10 ℃, add sodium isocyanate, and stir for 2 hours. Add hydrochloric acid to pH4-4.5 below 15 ℃. Then add activated carbon to decolorize and filter, add hydrochloric acid to the filtrate to pH1-2, cool to below 10 ℃, filter, wash, dry, and obtain carbarsine.
category
Toxic substances
Toxicity classification
Poisoning
Acute toxicity
oral-rat LD50: 510 mg/kg; Abdominal-rat LDL0: 1000 mg/kg
flammability hazard characteristics
Thermal decomposition discharges toxic nitrogen oxides and arsenide fumes
storage and transportation features
Warehouse low temperature ventilation and drying
Fire extinguishing agent
Water, carbon dioxide, foam, dry powder
occupational standards
TWA 0.5 mg (arsenic)/m3