Castor Oil Hydrogenated
Castor Oil Hydrogenated
CAS: 8001-78-3
Molecular Formula:
Castor Oil Hydrogenated - Names and Identifiers
Castor Oil Hydrogenated - Physico-chemical Properties
| Density | 0.97g/cm3 at 20℃ |
| Solubility | Practically insoluble in water; soluble in acetone,chloroform, and methylene chloride. |
| Vapor Presure | 0Pa at 20℃ |
| Appearance | Powder |
| Storage Condition | Room Temprature |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Use | For the production of daily cosmetics, shoe polish, pharmaceutical ointment, is the raw material for the preparation of 12-hydroxy stearic acid |
Castor Oil Hydrogenated - Risk and Safety
| HS Code | 1516200000 |
Castor Oil Hydrogenated - Upstream Downstream Industry
| Raw Materials | Sodium Chloride Hydrochloric acid |
| Downstream Products | 12-Hydroxystearic acid |
Castor Oil Hydrogenated - Reference
| Reference Show more | 1. Zeng Tianying, Huang Xingyu, Gao Shiqi, Peng Zhirong, Wu Huiting, Wang Yiting, Yan Hong. Comparative study on permeability and rheology of geniposide cubic liquid crystal gel and geniposide ointment in vitro [J]. Asia-Pacific traditional medicine, 2021,17(04):30-36. |
Castor Oil Hydrogenated - Introduction
Open Data Unverified Data
This product is prepared by hydrogenation of castor oil, and its main component is 12-hydroxystearic acid triglyceride. This product is white to light yellow powder, lumps or flakes. This product is slightly soluble in methylene chloride, insoluble in petroleum ether, very slightly soluble in ethanol, insoluble in water.
Last Update：2022-01-01 08:51:15
Castor Oil Hydrogenated - Physical and chemical properties
Open Data Unverified Data
- Appearance: white to pale yellow powder, lump or flake.
- Base number: not more than 4.0.
- Melting Point: 85-88 °c.
- hydroxyl value: 150-165.
- iodine value: not more than 5.0.
- saponification value: 176-182.
- color: 3
storage
Transport, storage should pay attention to fire, rain, to avoid damage, pollution.
Last Update：2022-01-01 08:51:16
Castor Oil Hydrogenated - Standard
Authoritative Data Verified Data
This line is prepared by hydrogenation of castor oil, and its main component is 12-hydroxystearic acid triglyceride.
Last Update：2024-01-02 23:10:35
Castor Oil Hydrogenated - Trait
Authoritative Data Verified Data
- This product is white to light yellow powder, lumps or flakes.
- This product is slightly soluble in dichloromethane, slightly soluble in ethanol, insoluble in water or petroleum ether.
Last Update：2022-01-01 11:24:04
Castor Oil Hydrogenated - Storage
Open Data Unverified Data
sealed, protected from light, stored in a cool and dry place. Keep away from fire sources and oxides.
Last Update：2022-01-01 08:51:16
Castor Oil Hydrogenated - Exam
Authoritative Data Verified Data
alkaline impurity
take this product l .O g, add ethanol 1 .5m l and toluene 3 m l, warm to dissolve, add 1 drop of 0.04% bromophenol blue ethanol solution, while hot with hydrochloric acid titration solution (0. O lm o l/L) titration until the solution turns yellow, consumption of hydrochloric acid titration solution (0. 01mol/L) should not pass 0. 2ml.
nickel
take an appropriate amount of nickel standard solution and use 0.5% dilute nitric acid quantitative dilution made per lml respectively containing 0, 0.005, 0. 025, 0. 050 and 0. 075mg solution, as a reference solution; Take this product 0.5g, precision weighing, plus nitric acid 10ml digestion, the digestion liquid water is transferred to the 25ml measuring flask, add 1ml each of 0.04mol/L magnesium nitrate solution and 0.87mol/L ammonium dihydrogen phosphate solution, dilute with water to the scale, shake well, and use as a test solution. Reagent blank solution prepared in the same method, according to Atomic Absorption Spectrophotometry (General 0406 first method), measured at 232. Onm wavelength, calculation, obtained. Nickel content should not exceed 5 parts per million.
Heavy metals
take this product l .O g, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 10 parts per million.
arsenic salt
take the product l .O g, put in l 50M l conical flask, add 5ml sulfuric acid, after heating and complete carbonization, add concentrated hydrogen peroxide solution Dropwise (if a large amount of foam occurs, stop heating and rotate the conical flask, the unreacted substances were prevented from caking at the bottom of the bottle) until the solution was colorless. Cool, carefully add 0822 of water, and then heat until sulfur trioxide gas appears, cool, slowly add appropriate amount of water to make 0.0002%, and check according to law (general rule, law 1), shall comply with the regulations ().
fatty acid composition
take this product O .lg, put in 50 m l Erlenmeyer flask, add 0. 5M o l/L sodium hydroxide methanol solution 2ml, heated and refluxed in 65°C water bath for about 30 minutes, allowed to cool, added 15% boron trifluoride methanol solution 2ml, heated and refluxed in 65°C water bath for 30 minutes, after heating and refluxing in a water bath at 65°C for 5 minutes, cool, add 10ml of saturated sodium chloride solution, shake well, stand still to make the layers, and take 2ml of the upper layer, the mixture was washed 3 times with water, 2ml each time, and the supernatant was dried over anhydrous sodium sulfate as a test solution. Test according to Gas chromatography (General 0521). The bonded polyethylene glycol is used as a stationary liquid, the initial temperature is 230 ° C., the temperature is maintained for 11 minutes, the temperature is raised to 250 ° C. At a rate of 5 ° C. Per minute, and the temperature of the injection port is 260 ° C; the detector temperature was 270°C. The reference substances of methyl palmitate, methyl stearate, methyl arachidate, methyl 12-oxystearate and methyl 12-hydroxystearate were dissolved and diluted with n-hexane to prepare 0. lm g solution, take l p l injection gas chromatograph, record chromatogram, theoretical plate number according to 12-hydroxystearic acid methyl ester peak calculation is not less than 10 000, the chromatographic peak separation degree should meet the requirements. The sample solution was injected into the gas chromatograph, and the chromatogram was recorded. According to the area normalization method, the palmitic acid was not more than 2-0%, and the stearic acid should be 7 .0 ~ 14.0%, arachidonic acid is not more than 1. 0%,12-oxygen stearic acid is not more than 5 .0%,12-hydroxystearic acid should be 78.0% to 91.0%, other fatty acids not more than 3 .0%.
Last Update：2022-01-01 11:24:05
Castor Oil Hydrogenated - Incompatibility
Open Data Unverified Data
This product is compatible with most natural plant waxes and Animal waxes.
Last Update：2022-01-01 08:51:16
Castor Oil Hydrogenated - Category
Authoritative Data Verified Data
pharmaceutical excipients, emulsifiers and ointment base.
Last Update：2022-01-01 11:24:05
Castor Oil Hydrogenated - Packaging
Open Data Unverified Data
double-layer light-protected polyethylene medical plastic bag, net weight 2kg/barrel, 5kg/barrel, 20kg/barrel.
Last Update：2022-01-01 08:51:17
Castor Oil Hydrogenated - Storage
Authoritative Data Verified Data
light shielding, closed storage.
Last Update：2022-01-01 11:24:05
Castor Oil Hydrogenated - Application examples
Open Data Unverified Data
used as sustained and controlled release material
1, naproxen controlled release tablets
immediate release granule formula: naproxen 300mg, lactose 880 mg,PVP 18 mg, starch 30 mg, sodium carboxymethyl starch 18 mg, magnesium stearate 1.2 mg;
controlled release granule formula: naproxen 450mg, hydrogenated castor oil 171 mg, ethyl cellulose 54 mg;
The above two kinds of granules were mixed well and tableted.
2, long-lasting Potassium Chloride Tablets
take the prescription amount of potassium chloride crystals suspended in molten cetyl alcohol, hydrogenated castor oil and stearic acid, and stir until nearly solidified to make particles through a 20-mesh sieve, the granules were then mixed with the gelatin solution and then passed through a 10-mesh sieve for granulation. After drying at room temperature, the tablet core was pressed with lubricant and finally coated with sugar.
3, N (a hydroxyethyl) nicotinic acid nitrate ester matrix tablets
take 90g of hydrogenated castor oil, disperse into fine particles with a diameter of 1.5 & micro;m with micromilling, mix immediately with 8g of hydroxypropyl cellulose, and granulate the mixture with 20g of 10% hydroxypropyl cellulose mixed with 43g of water, drying at 50 ℃ to prepare granule A; Take the above mixture A2.5g, add 7.5g of main drug to make granule B; Take 5.9g of lactose, 3g of microcrystalline cellulose, 0.1g of magnesium stearate and 1g of the main drug were mixed to prepare granules C; The granules A, B and C were mixed and compressed into tablets.
4, sustained-release coating material
a specific drug requires a coating layer to achieve a sustained-release effect. Hydrogenated castor oil is one of the commonly used sustained-release materials, and the general dosage is 5.0%-20.0% of the total weight of the coating layer.
used as lubricant
- hydrogenated castor oil can be used as a lubricant for tablets. Although its lubricating effect is not as good as that of magnesium stearate, hydrogenated castor oil is the best choice for a small number of tablets that produce viscoelasticity during tableting, for example, it is desirable to use hydrogenated castor oil as a lubricant Clopidogrel Hydrogen Sulphate Tablets.
- In fact, most drugs with strong polarity (drugs with strong hydrophilicity) and drugs that are easy to cause mottling during tableting, hydrogenated castor oil can be used as a lubricant, which can play a lubricating role, can also prevent the role of sticking, can also play a hydrophobic role is not easy to produce mottling.
- hydrogenated castor oil is generally used as a lubricant by an addition method, and the amount is generally 0.2% to 2%.
used as base in ointment or suppository
- a variety of vegetable oils such as castor oil, sesame oil, peanut oil and tea seed oil are often used as solvents or oil phase matrices in pharmaceutical preparations, but the long-term stability of pharmaceutical preparations is affected by the easy oxidation and rancidity of vegetable oils, based on solving the problem of easy oxidation and rancidity of vegetable oil, it was found that the product is not easy to oxidize and rancidity after hydrogenation of vegetable oil, and its oil performance does not change obviously.
- Therefore, in the ointment and suppository varieties, the need to use vegetable oil or liquid paraffin varieties can be used hydrogenated castor oil, because hydrogenated castor oil is a waxy solid, the consistency after melting is larger, therefore, the amount of grease or oil phase can be greatly reduced, and the paste is more smooth and fine.
Last Update：2022-01-01 08:51:18
Castor Oil Hydrogenated - Supplementary Information
Open Data Unverified Data
category toxic substances
Toxic grade poisoning
Acute toxicity intravenous injection-mouse LD50: 5000 mg/kg
Flammability hazard characteristics thermal decomposition spicy stimulation smoke
Storage and Transportation characteristics the warehouse was ventilated and dried at low temperature; Storage and transportation were separated from food raw materials
Fire extinguishing agent fog water, carbon dioxide, foam, dry powder
Last Update：2022-01-01 08:51:18
Castor Oil Hydrogenated - Reference Information
| LogP | 18.75 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | used in the production of daily cosmetics, shoe polish, pharmaceutical ointment, is the preparation of 12-hydroxystearic acid raw material |
| category | toxic substances |
| toxicity grade | low toxicity |
| Acute toxicity | intravenous-mouse LD50: 5000 mg/kg |
| flammability hazard characteristics | thermal decomposition of spicy and irritating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| extinguishing agent | dry powder, water, foam, carbon dioxide |
Last Update：2024-04-09 20:52:54
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View History
Castor Oil Hydrogenated
芬布锡
Polyhexamethyleneguanidine hydrochloride
H-PROLINOL
p-Chlorophenoxyacetic acid
芬布锡
Polyhexamethyleneguanidine hydrochloride
H-PROLINOL
p-Chlorophenoxyacetic acid
Raw Materials for Castor Oil Hydrogenated
Downstream Products for Castor Oil Hydrogenated