Cefcapene Pivoxil Hydrochloride Monohydrate

Cefcapene Pivoxil Hydrochloride Monohydrate - Names and Identifiers

Name	Cefcapene pivoxil hydrochloride
Synonyms	Flomox Cefcapene CEFCAPENE PIVOXIL HCL Cefcapene pivoxil hydrochloride Cefcapene pivoxil hydrochloride hydrate Cefcapene Pivoxil Hydrochloride Monohydrate 2,2-dimethylpropanoyloxymethyl 7-[2-(2-amino-1,3-thiazol-4-yl)pent-2-enoylamino]-3-(carbamoyloxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate [(2,2-dimethylpropanoyl)oxy]methyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino}-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride [(2,2-dimethylpropanoyl)oxy]methyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino}-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride hydrate (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, (2,2-Dimethyl-1-oxopropoxy)methyl Ester Hydrochloride 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester,(6R-(6-alpha,7-beta(Z)))-, monohydrochloride, hydrate
CAS	147816-24-8
EINECS	1592732-453-0
InChI	InChI=1/C23H29N5O8S2.ClH.H2O/c1-5-6-12(13-9-38-21(24)26-13)16(29)27-14-17(30)28-15(11(7-34-22(25)33)8-37-18(14)28)19(31)35-10-36-20(32)23(2,3)4;;/h6,9,14,18H,5,7-8,10H2,1-4H3,(H2,24,26)(H2,25,33)(H,27,29);1H;1H2/b12-6-;;/t14-,18-;;/m1../s1
InChIKey	LUXIJPQYUCFVAL-XRLCNELCSA-N

Cefcapene Pivoxil Hydrochloride Monohydrate - Physico-chemical Properties

Molecular Formula	C23H32ClN5O9S2
Molar Mass	622.11
Melting Point	158-164°C
Boling Point	888.4°C at 760 mmHg
Flash Point	491.1°C
Solubility	DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
Vapor Presure	3.51E-32mmHg at 25°C
Appearance	grayish white solid
Color	White to Off-White
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
In vivo study	Cefcapene pivoxil hydrochloride hydrate (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, it stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration. Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×10 9 CFU) Dosage: 100 mg/kg Administration: Oral administration; 100mg/kg; 4 days Result: Was against H. influenzae colonization in mouse lung.