Cefradine Impurity B(EP)
(R)-α-aminocyclohexa-1,4-diene-1-acetic acid
CAS: 26774-88-9
Molecular Formula: C8H11NO2
Cefradine Impurity B(EP) - Names and Identifiers
Cefradine Impurity B(EP) - Physico-chemical Properties
| Molecular Formula | C8H11NO2 |
| Molar Mass | 153.18 |
| Density | 1.1577 (rough estimate) |
| Melting Point | 280 °C (dec.) (lit.) |
| Boling Point | 276.1°C (rough estimate) |
| Specific Rotation(α) | -154 º (c=1 in H2O) |
| Flash Point | 122.8°C |
| Solubility | Aqueous Acid (Slightly) |
| Vapor Presure | 0.00107mmHg at 25°C |
| Appearance | neat |
| Color | White |
| BRN | 2091420 |
| pKa | 2.17±0.10(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | -155 ° (C=1, 1mol/L |
| MDL | MFCD00137746 |
| Physical and Chemical Properties | Appearance: white or off-white powder |
| Use | Used in the manufacture of cefradine. |
Cefradine Impurity B(EP) - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
Cefradine Impurity B(EP) - Reference Information
| Introduction | (R)-(-)-2-(2, 5-dihydrophenyl) glycine, commonly known as dihydrophenylglycine, is an important intermediate of cefradine, which is obtained by hydrogenation reduction of D(-)-phenylglycine. |
| preparation | at present, the domestic production process of (R)-(-)-2-(2,5-dihydrophenyl) glycine is 1500~1700 L liquid ammonia mixed with 300~400 L water cooling (vacuum cooling with ammonia compressor or vacuum pump) to below -30 ℃, add 40 kgD(-)-phenylglycine, then add 22~32kg of metal sodium in batches, control the temperature below -15 ℃ for reaction for more than 1 h, recover liquid ammonia after the reaction, decolorize at 30 ℃ ~ 50 ℃ for more than 30 min, filter, adjust the pH to 6.5~6.8 with hydrochloric acid below 35 ℃, cool to below 15 ℃ and spin dry centrifugally, wash and spin dry with purified water, and dry with wet product air dryer. |
| use | used as the main intermediate for the production of drug pioneer 6 |
Last Update：2024-04-09 21:32:05
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Product Name: Cefradine Impurity 2（Cefradine EP Impurity B） Visit Supplier Webpage Request for quotationCAS: 26774-88-9
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Mobile: 86+15671228036
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Wechat: 15671228036
Product Name: (R)-(-)-2-Amino-2-(Cyclohexa-1,4-Dienyl)Acetic Acid Visit Supplier Webpage Request for quotation
CAS: 26774-88-9
Tel: 18301782025
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CAS: 26774-88-9
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