Cholest-5-ene-3,22-diol, (3beta,22R)-
22(R)-hydroxycholesterol
CAS: 17954-98-2
Molecular Formula: C27H46O2
Cholest-5-ene-3,22-diol, (3beta,22R)- - Names and Identifiers
| Name | 22(R)-hydroxycholesterol |
| Synonyms | 22R-OHC 22(R)-hydroxycholesterol Cholest-5-ene-3β,22(R)-diol (22R)-Cholest-5-ene-3β,22-diol (3β,22R)-Cholest-5-ene-3,22-diol (20S,22R)-Cholest-5-ene-3β,22-diol (3beta,22R)-Cholest-5-ene-3,22-diol Cholest-5-ene-3,22-diol, (3beta,22R)- 22α-Hydroxycholesterol, 5-Cholestene-3β,22(R)-diol, 5-Cholestene-3β,22[R]-diol |
| CAS | 17954-98-2 |
| InChI | InChI=1/C27H46O2/c1-17(2)7-6-8-18(3)22-11-12-23-21-10-9-19-15-20(28)16-25(29)27(19,5)24(21)13-14-26(22,23)4/h9,17-18,20-25,28-29H,6-8,10-16H2,1-5H3/t18-,20-,21+,22-,23+,24+,25?,26-,27+/m1/s1 |
| InChIKey | RZPAXNJLEKLXNO-QUOSNDFLSA-N |
Cholest-5-ene-3,22-diol, (3beta,22R)- - Physico-chemical Properties
| Molecular Formula | C27H46O2 |
| Molar Mass | 402.65 |
| Melting Point | 171-174°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | -20°C |
| Refractive Index | 1.536 |
Cholest-5-ene-3,22-diol, (3beta,22R)- - Risk and Safety
| WGK Germany | 3 |
Cholest-5-ene-3,22-diol, (3beta,22R)- - Introduction
22(R)-hydroxycholesterol is a compound with a special structure, also known as 22(R)-hydroxycholerone. Its chemical formula is C27H46O2.
In terms of properties, 22(R)-hydroxycholesterol is a derivative of cholesterol. It is a colorless crystalline solid which is soluble in organic solvents such as methanol, ethanol and chloroform at room temperature. It is extremely rare in nature and can be found in sponges.
This compound has a wide range of applications in the field of medicine. Due to its special structure, it is used as a precursor of anti-cancer drugs and can exert anti-tumor effects. In addition, 22(R)-hydroxycholesterol is also used for the preparation of cholesterol ester compounds, and thus for the identification and determination of compounds in some organisms.
In terms of preparation, 22(R)-hydroxycholesterol can be synthesized by different methods, such as Enzyme-catalyzed asymmetric synthesis. These methods are mainly based on the modification and conversion of cholesterol.
Regarding safety information, the toxicological data of 22(R)-hydroxycholesterol is relatively limited, so it is necessary to follow the general laboratory operation precautions when using it. At the same time, its toxicity, biological activity and the effects of long-term exposure still need to be further studied and evaluated. When using and handling, it should be operated in strict accordance with relevant safety guidelines and regulations.
In terms of properties, 22(R)-hydroxycholesterol is a derivative of cholesterol. It is a colorless crystalline solid which is soluble in organic solvents such as methanol, ethanol and chloroform at room temperature. It is extremely rare in nature and can be found in sponges.
This compound has a wide range of applications in the field of medicine. Due to its special structure, it is used as a precursor of anti-cancer drugs and can exert anti-tumor effects. In addition, 22(R)-hydroxycholesterol is also used for the preparation of cholesterol ester compounds, and thus for the identification and determination of compounds in some organisms.
In terms of preparation, 22(R)-hydroxycholesterol can be synthesized by different methods, such as Enzyme-catalyzed asymmetric synthesis. These methods are mainly based on the modification and conversion of cholesterol.
Regarding safety information, the toxicological data of 22(R)-hydroxycholesterol is relatively limited, so it is necessary to follow the general laboratory operation precautions when using it. At the same time, its toxicity, biological activity and the effects of long-term exposure still need to be further studied and evaluated. When using and handling, it should be operated in strict accordance with relevant safety guidelines and regulations.
Last Update：2024-04-10 22:30:50
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