Chondroitin sulfate A sodium salt
Chondroitin sulfate sodium salt
CAS: 9082-07-9;39455-18-0
Molecular Formula: C42H57N3Na6O43S3X2
Chondroitin sulfate A sodium salt - Names and Identifiers
Chondroitin sulfate A sodium salt - Physico-chemical Properties
| Molecular Formula | C42H57N3Na6O43S3X2 |
| Molar Mass | 1526.03 |
| Melting Point | >205°C (dec.) |
| Solubility | H2O: 10 mg/mL. Soluble in water. Insoluble in organic solvents such as acetone and ethanol. |
| Appearance | White or white-like powder |
| Color | White to Off-White |
| PH | 5.5 to 7.5 (10g/L, 25 ℃) |
| Storage Condition | 2-8°C |
| Sensitive | Easy to absorb moisture; `sensitive` to heat |
| MDL | MFCD01310245 |
| Use | For the regulation of blood lipids, anti-atherosclerosis |
Chondroitin sulfate A sodium salt - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | GA8410000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 30019090 |
Chondroitin sulfate A sodium salt - Reference
| Reference Show more | 1. Gongreze, Qi Yili, Huo Xiaohui, et al. Study on extraction, separation and antioxidant activity of chondroitin sulfate from deer trachea [J]. Food Science & Technology, 2019, 044(001):291-296. |
Chondroitin sulfate A sodium salt - Nature
Open Data Verified Data
- This product is an acidic mucopolysaccharide obtained from cartilage tissue of animals, in which monosaccharides are mainly D glucuronic acid and 2-amino -2-deoxy-D-galactose, and there are equal amounts of acetyl and sulfate groups. It contains about 50~70 basic units of disaccharides, and the relative molecular mass is 10000~300000. Medicinal Products for the chondroitin sulfate A, D and other mixtures. Gray-white amorphous powder, slightly salty; Odorless; With hygroscopicity. The aqueous solution of this product is viscous and does not coagulate when heated. Soluble in water, insoluble in ethanol, acetone or acetic acid.
- According to the difference of its chemical composition and structure, chondroitin sulfate is divided into A, B, C, D, E, F, H, etc, the H molecule contains L-iduronic acid. B is not degraded by the enzyme, and the color reaction is different from A. B is called dermatan sulfate, which is more in the skin. Pharmaceutical chondroitin sulfate is extracted from animal cartilage, mainly A, C and A mixture of various chondroitin sulfate. It has a clear lipid, improve the body's detoxification function, diuretic and analgesic effects, effective for collagen disorders, also has the effect of hearing impairment caused by streptomycin.
Last Update：2024-01-02 23:10:35
Chondroitin sulfate A sodium salt - Preparation Method
Open Data Verified Data
40kg of white dry cartilage was added to a 2% NaOH solution (250kg), extracted with stirring at room temperature at intervals, and filtered. The residue was then soaked in an appropriate amount of distilled water and filtered. The two filtrates were combined to make the total volume of the filtrate 200L. To the above filtrate, 1:1 hydrochloric acid was added to adjust the pH to 8.8 to 9.0, and the mixture was heated. At 50 ° C., 13 0G of Pancreatin corresponding to 1:250 times was added. Continue to raise the temperature, control the temperature at 53~54 degrees C, hydrolysis 7H. In the hydrolysis process, due to the increase of amino acids, so that the pH drops, the need to use 10% sodium hydroxide solution at any time to adjust the pH 8.8~9.0. After the hydrolysis is completed, the temperature is maintained at 53~54 ℃, and the pH is adjusted to 6.8~7.0 with 1:2 hydrochloric acid, then 7kg of activated clay and 200g of activated carbon are added and stirred, then, the pH was readjusted to 10% -7.0 with 6.8 sodium hydroxide solution, and th was adsorbed with stirring. The pH was again adjusted to 5.4 with 1:2 hydrochloric acid, the heating was stopped, left for a moment, and filtered. The filtrate was rapidly adjusted to pH 6.0 with 1% sodium hydroxide solution, and 1% sodium chloride solution by volume of the filtrate was added, dissolved, and filtered until clear. Ethanol was added to the filtrate with stirring so that the alcohol content was 75%, and the mixture was stirred once every 0.5H for 4 to 6 times. After standing for more than 8H, chondroitin sulfate precipitates and the supernatant is siphled out. Chondroitin sulfate precipitation is fully dehydrated with anhydrous ethanol for 2 times, dried, dried at 60~65 ℃ or vacuum dried to obtain a finished product.
Last Update：2022-01-01 11:13:19
Chondroitin sulfate A sodium salt - Use
Open Data Verified Data
for some nerve headache, neuralgia, Arthralgia, migraine, atherosclerosis, etc.; Can also be used for streptomycin induced hearing impairment and hepatitis and other adjuvant therapy.
Last Update：2022-01-01 11:13:19
Chondroitin sulfate A sodium salt - Safety
Open Data Verified Data
light-shielded, sealed, and stored in a dry place.
Last Update：2022-01-01 11:13:19
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