Chonglouoside Ⅶ
Paris Saponin VII
CAS: 68124-04-9
Molecular Formula: C51H82O21
Chonglouoside Ⅶ - Names and Identifiers
Chonglouoside Ⅶ - Physico-chemical Properties
| Molecular Formula | C51H82O21 |
| Molar Mass | 1031.2 |
| Density | 1.45±0.1 g/cm3(Predicted) |
| Melting Point | 243-245 °C (decomp) |
| Appearance | Powder |
| pKa | 12?+-.0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Chemical properties of white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the heavy building. |
| Use | Uses Paris saponin Ⅶ poly source anti-inflammatory, anti-tumor, anti-virus, lowering cholesterol, lowering blood pressure and other effects. |
Chonglouoside Ⅶ - Risk and Safety
| HS Code | 29329990 |
Chonglouoside Ⅶ - Reference
| Reference Show more | 1. Liu Jia, Yang Yali, Zhang Peng, et al. Analysis of the content of saponins in different parts of 4 kinds of Paris polyphylla [J]. Chinese Journal of Experimental formulology, 2016, Vol. 22, 16, pages 44-48. 2. Wang Haiming, et al. Determination of four saponins in Rhizoma Paridis by HPLC [J]. Journal of Dalian Minzu University, 2018, 20(001):17-20. 3. Ye Feifei, Xu Haobo, Wang Chunxia, et al. Simultaneous determination and cluster analysis of four saponins from Paris polyphylla [J]. Chinese patent medicine 2016 38(11):2413-2413. 4. Liu Jia, Zhang Peng, Song Fa-Jun, etc. Analysis of the content of four kinds of saponins in the ground part of Paris polyphylla [J]. Shi Zhen, National Medicine, 2015, 026(005):1233-1235. 5. Liu Xiaofen, Huang Xiaozhi, Wang Heshan. Quality Evaluation and Analysis of cultivated Paridis in Fujian province [J]. Fujian Traditional Chinese Medicine, 2012, 43(005):53-55. 6. Wang Shibao, Cai Yanni, Jia Huimei et al. Determination of seven steroidal saponins in Rhizoma Paridis from different sources by HPLC [J]. Northwest Pharmaceutical Journal, 2017, 32(002):133-138. 7. Liu Tianyi, Li Li, Ma Maoqiang, Yang Fei, Guo gongling, Wang Xin, Zhang xuesun. Quality control of Zhongqi colon targeting pellets and intervention on DSS-induced UC model in mice [J]. Chinese Medicine Review, 2021,27(01):73-78. 8. Hu Shishang, Zhou Yuanyuan, Wu Zihao, Zhu Min, Yu Xueyan, du buyu, Yu Qingqing. Effect of polyphylla saponin VII on pancreatic cancer cells [J]. Journal of Hubei University of Medicine and Pharmacy, 2020,39(06): 528 9. Liu, Feng, et al. "Comparative analysis of proteinic and metabolic profiles of different species of Paris." Journal of proteomics 200 (2019): 11-27.https:// doi.org/10.1016/j. Jprot.23/2019 10. Liu, Feng, et al. "Comparative analysis of proteinic and metabolic profiles of different species of Paris." Journal of proteomics 200 (2019): 11-27.https://doi.org/10.1016/j.jprot.2019.02.003 11. [IF=4.072] Yan Yin et al."A cytochrome P450 monooxygenase responsible for the C- 22 hydroxylation step in the Paris polyphylla steroidal saponin biosynthesis pathway."Phytochemistry. 2018 Dec;156:116 12. [IF=4.044] Feng Liu et al."Comparative analysis of proteomic and metabolomic profiles of different species of Paris."J Proteomics. 2019 May;200:11 13. [IF=6.15] Xiang Yu-chen et al."Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells."Acta Pharmacol Sin. 2021 Sep;:1-13 14. [IF=5.645] Bo Li et al."Organ-specific transcriptome sequencing and mining of genes involved in polyphyllin biosynthesis in Paris polyphylla."Ind Crop Prod. 2020 Nov;156:112775 15. [IF=4.242] Shun Zhou et al."Anthelmintic efficacy of 35 herbal medicines against a monogenean parasite, Gyrodactylus kobayashii, infecting goldfish (Carassius auratus)."Aquaculture. 2020 May;521:734992 16. [IF=3] Xin ZHANG et al."Biopharmaceutics classification evaluation for paris saponin VII."Chin J Nat Medicines. 2020 Sep;18:714 17. [IF=3] Yu-Chen XIANG et al."Paris saponin VII, a direct activator of AMPK induces autophagy and exhibits therapeutic potential in non-small-cell lung cancer."Chin J Nat Medicines. 2021 Mar;19:195 18. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150 19. [IF=10.435] Bai Shaobo et al.MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer.J Nanobiotechnol. 2021 Dec;19(1):1-20 20. [IF=4.412] Feng Su et al."Study of Chemical Compositions and Anticancer Effects of Paris polyphylla var. Chinensis Leaves."MOLECULES. 2022 Jan;27(9):2724 |
Chonglouoside Ⅶ - Uses and synthesis methods
biological activity
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the root and rhizome of Trillium (Trillium tschonoskii Maxim). Apoptosis of K562/ADR cells induced by Paris saponin VII is related to the inhibition of Akt/p38 MAPK and P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-associated proteins (Bax and cytochrome c), and decreases the protein expression levels of Bcl-2,caspase-9,caspase-3,PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.
Target
Aktp38Bcl-2Caspase-9Caspase-3PARP-1
in vitro studies
Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase.
In vivo studies
Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.
Last Update：2024-04-09 01:59:51
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Product Name: Chonglou Saponin VII Visit Supplier Webpage Request for quotationCAS: 68124-04-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Paris saponin VII (Standard) Visit Supplier Webpage Request for quotationCAS: 68124-04-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Polyphyllin VII Visit Supplier Webpage Request for quotationCAS: 68124-04-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
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Product Name: Paris Saponin VII Visit Supplier Webpage Request for quotationCAS: 68124-04-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
Chonglouoside Ⅶ
SODIUM BENZOHYDROXAMATE HYDRATE
甲基丙烯酸苄基酯
苝大红
2769-64-4
Abemaciclib
乙烯基甲苯
TIMTEC-BB SBB007740
4-Piperidinecarboxaldehyde, 1-(1-methylethyl)- (9CI)
-cyclohexanecarboxami
SODIUM BENZOHYDROXAMATE HYDRATE
甲基丙烯酸苄基酯
苝大红
2769-64-4
Abemaciclib
乙烯基甲苯
TIMTEC-BB SBB007740
4-Piperidinecarboxaldehyde, 1-(1-methylethyl)- (9CI)
-cyclohexanecarboxami